5-AMINO-4-CYANO-3-METHYL-THIOPHENE-2-CARBOXYLIC ACID ETHYL ESTER

Base Information

• Chemical Name: 5-AMINO-4-CYANO-3-METHYL-THIOPHENE-2-CARBOXYLIC ACID ETHYL ESTER
• CAS No.: 23903-46-0
• Molecular Formula: C9H10 N2 O2 S
• Molecular Weight: 210.25
• Hs Code.: 29349990
• Mol file: 23903-46-0.mol

Synonyms:3-Methyl-4-cyano-5-aminothiophene-2-carboxylicacid ethyl ester

Chemical Property of 5-AMINO-4-CYANO-3-METHYL-THIOPHENE-2-CARBOXYLIC ACID ETHYL ESTER

Chemical Property:

• Vapor Pressure: 3.49E-06mmHg at 25°C
• Melting Point: 151 °C
• Boiling Point: 386.6°Cat760mmHg
• PKA: -2.25±0.10(Predicted)
• Flash Point: 187.6°C
• PSA: 104.35000
• Density: 1.29g/cm³
• LogP: 2.26828
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

ethyl5-amino-4-cyano-3-methylthiophene-2-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-AMINO-4-CYANO-3-METHYL-THIOPHENE-2-CARBOXYLIC ACID ETHYL ESTER

There total 3 articles about 5-AMINO-4-CYANO-3-METHYL-THIOPHENE-2-CARBOXYLIC ACID ETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

ethyl acetoacetate (141-97-9) + malononitrile (109-77-3) → ethyl 2-amino-3-cyano-4-methylthiophene-5-carboxylate (23903-46-0)

Guidance literature:

With piperidine; sulfur; In ethanol; for 3h; Heating;

Reference yield:

diethyl 1,3-acetonedicarboxylate (105-50-0) + malononitrile (109-77-3) → ethyl 2-amino-3-cyano-4-methylthiophene-5-carboxylate (23903-46-0) + ethyl 5-amino-4-cyano-3-(2-ethoxy-2-oxoethyl) thiophene-2-carboxylate (58168-20-0)

Guidance literature:

diethyl 1,3-acetonedicarboxylate; malononitrile; With morpholine; In N,N-dimethyl-formamide; at 25 - 35 ℃;

With sulfur; In N,N-dimethyl-formamide; at 25 - 55 ℃;

With water; In N,N-dimethyl-formamide; at 25 - 55 ℃;

Reference yield:

→ ethyl 2-amino-3-cyano-4-methylthiophene-5-carboxylate (23903-46-0)

Guidance literature:

Acetessigsaeure-ethylester, Schwefel, Malonitril, Diethylamin in A.; Erwaermen;

DOI:10.1039/j39690001937

upstream raw materials:

ethyl acetoacetate

malononitrile

diethyl 1,3-acetonedicarboxylate

Downstream raw materials:

5-Methyl-3,4-dihydrothieno<2,3-d>pyrimid-4-one-6-carboxylic acid

ethyl 5-methyl-4-morpholinothieno[2,3-d]pyrimidine-6-carboxylate