Pyrimidine, 5-propyl-2-[(2S,4R)-2-[[(2,4,5-trifluorophenyl)methoxy]methyl]-4-[(triphen ylmethyl)thio]-1-pyrrolidinyl]-

Base Information

Chemical Name:Pyrimidine, 5-propyl-2-[(2S,4R)-2-[[(2,4,5-trifluorophenyl)methoxy]methyl]-4-[(triphen ylmethyl)thio]-1-pyrrolidinyl]-
CAS No.:391889-21-7
Molecular Formula:C38H36F3N3OS
Molecular Weight:639.785
Hs Code.:
Mol file:391889-21-7.mol

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Pyrimidine, 5-propyl-2-[(2S,4R)-2-[[(2,4,5-trifluorophenyl)methoxy]methyl]-4-[(triphen ylmethyl)thio]-1-pyrrolidinyl]-

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Technology Process of Pyrimidine, 5-propyl-2-[(2S,4R)-2-[[(2,4,5-trifluorophenyl)methoxy]methyl]-4-[(triphen ylmethyl)thio]-1-pyrrolidinyl]-

There total 6 articles about Pyrimidine, 5-propyl-2-[(2S,4R)-2-[[(2,4,5-trifluorophenyl)methoxy]methyl]-4-[(triphen ylmethyl)thio]-1-pyrrolidinyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 219555-98-3
2-chloro-5-propylpyrimidine

: 391888-89-4
(2S,4R)-2-(2,4,5-Trifluoro-benzyloxymethyl)-4-tritylsulfanyl-pyrrolidine

: 391889-21-7
(2S,4R)-5-propyl-2-[2-(2,4,5-trifluorobenzyloxymethyl)-4-tritylsulfanylpyrrolidin-1-yl]pyrimidine

Guidance literature:: With copper(l) iodide; N-ethyl-N,N-diisopropylamine; at 80 ℃; for 10h;
DOI:10.1021/jm040857x

Reference yield:

: 74844-91-0
1-tert-butyl 2-methyl (2S,4R)-4-hydroxy-1,2-pyrrolidinedicarboxylate

: 391889-21-7
(2S,4R)-5-propyl-2-[2-(2,4,5-trifluorobenzyloxymethyl)-4-tritylsulfanylpyrrolidin-1-yl]pyrimidine

Guidance literature:: Multi-step reaction with 6 steps

1.1: 89 percent / CCl₄; PPh₃ / CH₂Cl₂ / 4 h / 3 - 35 °C

2.1: KO-t-Bu / dimethylformamide / 0.33 h / 20 °C

2.2: 83 percent / dimethylformamide / 3.25 h / 0 - 20 °C

3.1: 100 percent / LiAlH₄ / tetrahydrofuran / 0.33 h / -20 °C

4.1: 70 percent / NaH / dimethylformamide / 0 - 20 °C

5.1: 100 percent / trifluoroacetic acid / CH₂Cl₂ / 5.5 h / -20 - 20 °C

6.1: 81 percent / N-ethyldiisopropylamine; copper(I) iodide / 10 h / 80 °C

With tetrachloromethane; copper(l) iodide; lithium aluminium tetrahydride; potassium tert-butylate; sodium hydride; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm040857x

Reference yield:

: 337307-10-5
(2S,4R)-2-Hydroxymethyl-4-tritylsulfanyl-pyrrolidine-1-carboxylic acid tert-butyl ester

: 391889-21-7
(2S,4R)-5-propyl-2-[2-(2,4,5-trifluorobenzyloxymethyl)-4-tritylsulfanylpyrrolidin-1-yl]pyrimidine

Guidance literature:: Multi-step reaction with 3 steps

1: 70 percent / NaH / dimethylformamide / 0 - 20 °C

2: 100 percent / trifluoroacetic acid / CH₂Cl₂ / 5.5 h / -20 - 20 °C

3: 81 percent / N-ethyldiisopropylamine; copper(I) iodide / 10 h / 80 °C

With copper(l) iodide; sodium hydride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm040857x