4-Thiazolemethanol,4,5-dihydro-2-(2-hydroxyphenyl)-, (4R)-

Base Information

Chemical Name:4-Thiazolemethanol,4,5-dihydro-2-(2-hydroxyphenyl)-, (4R)-
CAS No.:112515-23-8
Molecular Formula:C10H11 N O2 S
Molecular Weight:209.269
Hs Code.:

Synonyms:4-Thiazolemethanol,4,5-dihydro-2-(2-hydroxyphenyl)-, (R)-; (+)-(R)-Aerugine; (+)-Aerugine; 2-(2-Hydroxyphenyl)-4,5-dihydrothiazole-4-methanol;Aerugine

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Chemical Property of 4-Thiazolemethanol,4,5-dihydro-2-(2-hydroxyphenyl)-, (4R)-

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

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Technology Process of 4-Thiazolemethanol,4,5-dihydro-2-(2-hydroxyphenyl)-, (4R)-

There total 3 articles about 4-Thiazolemethanol,4,5-dihydro-2-(2-hydroxyphenyl)-, (4R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 115921-07-8
(R)-2-(2'-hydroxyphenyl)-4-methoxycarbonyl-4,5-dihydrothiazole

: 112515-23-8
(R)-2-(2-hydroxyphenyl)-4-hydroxymethyl-4,5-dihydrothiazole

Guidance literature:: With lithium aluminium tetrahydride; In diethyl ether; for 1h;
DOI:10.1248/cpb.c14-00578

Reference yield:

: 115921-06-7
(R)-2-(2-hydroxyphenyl)-4,5-dihydro-1,3-thiazole-4-carboxylic acid

: 112515-23-8
(R)-2-(2-hydroxyphenyl)-4-hydroxymethyl-4,5-dihydrothiazole

Guidance literature:: Multi-step reaction with 2 steps

1: 93 percent / acetyl chloride / 24 h / 50 °C

2: 60 percent / sodium borohydride; methanol / tetrahydrofuran / Heating

With methanol; sodium tetrahydroborate; acetyl chloride; In tetrahydrofuran; 1: Methylation / 2: Reduction;
DOI:10.1016/S0040-4020(99)00946-1

Reference yield:

: methyl 2-hydroxybenzimidate hydrochloride

: 112515-23-8
(R)-2-(2-hydroxyphenyl)-4-hydroxymethyl-4,5-dihydrothiazole

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 24 h / 20 °C / Reflux

2: lithium aluminium tetrahydride / diethyl ether / 1 h

With lithium aluminium tetrahydride; triethylamine; In diethyl ether; dichloromethane;
DOI:10.1248/cpb.c14-00578