2-Methyl-benzo[h]quinolin-4-ol

Base Information

• Chemical Name: 2-Methyl-benzo[h]quinolin-4-ol
• CAS No.: 3919-49-1
• Molecular Formula: C14H11NO
• Molecular Weight: 209.24300
• NSC Number: 159206
• DSSTox Substance ID: DTXSID40303582
• Wikidata: Q82048940
• ChEMBL ID: CHEMBL1450671
• Mol file: 3919-49-1.mol

Synonyms:2-Methyl-benzo[h]quinolin-4-ol;3919-49-1;2-methylbenzo[h]quinolin-4-ol;benzo[h]quinolin-4-ol, 2-methyl-;NSC159206;BAS 00471114;Oprea1_476937;Oprea1_859365;MLS000068564;CHEMBL1450671;DTXSID40303582;HMS2389G15;STK373634;AKOS000507451;NSC-159206;SMR000122961;SR-01000311979;SR-01000311979-1;F1920-0027

Chemical Property of 2-Methyl-benzo[h]quinolin-4-ol

Chemical Property:

• Vapor Pressure: 6.05E-06mmHg at 25°C
• Boiling Point: 379oC at 760 mmHg
• Flash Point: 160.3oC
• PSA: 33.12000
• Density: 1.201g/cm3
• LogP: 3.40200
• XLogP3: 3.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 209.084063974
• Heavy Atom Count: 16
• Complexity: 334

Purity/Quality:

97% ^*data from raw suppliers

2-METHYLBENZO[H]QUINOLIN-4-OL 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=O)C2=C(N1)C3=CC=CC=C3C=C2

Technology Process of 2-Methyl-benzo[h]quinolin-4-ol

There total 6 articles about 2-Methyl-benzo[h]quinolin-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

ethyl acetoacetate (141-97-9) + 1-amino-naphthalene (134-32-7) → 2-methyl-1H-benzo[h]quinolin-4-one (3919-49-1,58596-47-7)

Guidance literature:

With acidic styrol NKC-9 resin; In neat (no solvent); at 20 ℃; for 0.025h; Microwave irradiation;

DOI:10.14233/ajchem.2013.oh9

Reference yield:

3-[1]naphthylamino-crotonic acid ethyl ester (118176-47-9) → 2-methyl-benzo[h]quinolin-4-ol (3919-49-1)

Guidance literature:

With hydrogenchloride;

Reference yield:

(E)-3-(Naphthalen-1-ylamino)-but-2-enoic acid ethyl ester → 2-methyl-benzo[h]quinolin-4-ol (3919-49-1)

Guidance literature:

In diphenylether; at 250 ℃;

DOI:10.1039/c2md20270k

upstream raw materials:

3-[1]naphthylamino-crotonic acid ethyl ester

1-amino-naphthalene

ethyl acetoacetate