Carbamic acid, [1-[4-[(5S)-5-[(acetylamino)methyl]-2-oxo-3-oxazolidinyl]-2-fluorophenyl]- 4-piperidinyl]methyl-, 1,1-dimethylethyl ester

Base Information

Chemical Name:Carbamic acid, [1-[4-[(5S)-5-[(acetylamino)methyl]-2-oxo-3-oxazolidinyl]-2-fluorophenyl]- 4-piperidinyl]methyl-, 1,1-dimethylethyl ester
CAS No.:392660-26-3
Molecular Formula:C₂₃H₃₃FN₄O₅
Molecular Weight:464.537
Hs Code.:
Mol file:392660-26-3.mol

Carbamic acid,
[1-[4-[(5S)-5-[(acetylamino)methyl]-2-oxo-3-oxazolidinyl]-2-fluorophenyl]-
4-piperidinyl]methyl-, 1,1-dimethylethyl ester

Synonyms:

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Chemical Property of Carbamic acid, [1-[4-[(5S)-5-[(acetylamino)methyl]-2-oxo-3-oxazolidinyl]-2-fluorophenyl]- 4-piperidinyl]methyl-, 1,1-dimethylethyl ester

Chemical Property:

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Technology Process of Carbamic acid, [1-[4-[(5S)-5-[(acetylamino)methyl]-2-oxo-3-oxazolidinyl]-2-fluorophenyl]- 4-piperidinyl]methyl-, 1,1-dimethylethyl ester

There total 10 articles about Carbamic acid, [1-[4-[(5S)-5-[(acetylamino)methyl]-2-oxo-3-oxazolidinyl]-2-fluorophenyl]- 4-piperidinyl]methyl-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 392660-20-7
[1-(4-amino-2-fluoro-phenyl)-piperidin-4-yl]-methyl-carbamic acid tert-butyl ester

: 392660-26-3
(1-{4-[5-(acetylamino-methyl)-2-oxo-oxazolidin-3-yl]-2-fluoro-phenyl}-piperidin-4-yl)-methyl-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: NaHCO₃ / tetrahydrofuran

2.1: n-BuLi / tetrahydrofuran / 1.5 h / -78 °C

2.2: tetrahydrofuran

3.1: TEA / CH₂Cl₂ / 0 - 20 °C

4.1: NaN₃ / dimethylformamide / 80 °C

5.1: H₂ / Pd/C / methanol / 20 °C / 2844.31 Torr

6.1: TEA / CH₂Cl₂ / 0 - 20 °C

With n-butyllithium; sodium azide; TEA; hydrogen; sodium hydrogencarbonate; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2005.06.063

Reference yield:

: 392660-18-3
3-fluoro-4-((4-BOC-amino)piperidino)nitrobenzene

: 392660-26-3
(1-{4-[5-(acetylamino-methyl)-2-oxo-oxazolidin-3-yl]-2-fluoro-phenyl}-piperidin-4-yl)-methyl-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium hydride; tetrabutylammonium iodide / tetrahydrofuran / 0 °C

2.1: H₂ / Pd/C / methanol / 20 °C / 2844.31 Torr

3.1: NaHCO₃ / tetrahydrofuran

4.1: n-BuLi / tetrahydrofuran / 1.5 h / -78 °C

4.2: tetrahydrofuran

5.1: TEA / CH₂Cl₂ / 0 - 20 °C

6.1: NaN₃ / dimethylformamide / 80 °C

7.1: H₂ / Pd/C / methanol / 20 °C / 2844.31 Torr

8.1: TEA / CH₂Cl₂ / 0 - 20 °C

With n-butyllithium; sodium azide; TEA; hydrogen; tetra-(n-butyl)ammonium iodide; sodium hydride; sodium hydrogencarbonate; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2005.06.063

Reference yield:

: 392660-19-4
[1-(2-fluoro-4-nitro-phenyl)-piperidin-4-yl]-methyl-carbamic acid tert-butyl ester

: 392660-26-3
(1-{4-[5-(acetylamino-methyl)-2-oxo-oxazolidin-3-yl]-2-fluoro-phenyl}-piperidin-4-yl)-methyl-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: H₂ / Pd/C / methanol / 20 °C / 2844.31 Torr

2.1: NaHCO₃ / tetrahydrofuran

3.1: n-BuLi / tetrahydrofuran / 1.5 h / -78 °C

3.2: tetrahydrofuran

4.1: TEA / CH₂Cl₂ / 0 - 20 °C

5.1: NaN₃ / dimethylformamide / 80 °C

6.1: H₂ / Pd/C / methanol / 20 °C / 2844.31 Torr

7.1: TEA / CH₂Cl₂ / 0 - 20 °C

With n-butyllithium; sodium azide; TEA; hydrogen; sodium hydrogencarbonate; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2005.06.063