(2S,4R)-tert-butyl 4-hydroxypyrrolidine-2-carboxylate

Base Information

Chemical Name:(2S,4R)-tert-butyl 4-hydroxypyrrolidine-2-carboxylate
CAS No.:393154-87-5
Molecular Formula:C₉H₁₇NO₃
Molecular Weight:187.239
Hs Code.:
Mol file:393154-87-5.mol

Synonyms:(2S,4R)-4-Hydroxy-pyrrolidine-2-carboxylic acid tert-butyl ester;tert-butyl (2S,4R)-4-hydroxyprolinate;

Suppliers and Price of (2S,4R)-tert-butyl 4-hydroxypyrrolidine-2-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 3 raw suppliers

Chemical Property of (2S,4R)-tert-butyl 4-hydroxypyrrolidine-2-carboxylate

Chemical Property:

Boiling Point:279.7±40.0 °C(Predicted)
PKA:14.44±0.40(Predicted)
PSA：58.56000
Density:1.108±0.06 g/cm3(Predicted)
LogP:0.37970

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2S,4R)-tert-butyl 4-hydroxypyrrolidine-2-carboxylate

There total 3 articles about (2S,4R)-tert-butyl 4-hydroxypyrrolidine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 72289-52-2
(2S,4R)-4-hydroxy-1-phenylmethoxycarbonylpyrrolidine-2-carboxylic acid tert-butyl ester

: 393154-87-5
ert-butyl 4-hydroxypyrrolidine-2-carboxylate

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; for 2h;
DOI:10.1021/jo00092a022

Reference yield:

: 51-35-4,30724-02-8
4R-4-hydroxyproline

: 393154-87-5
ert-butyl 4-hydroxypyrrolidine-2-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: NaHCO₃ / H₂O / 2 h

2: tetrahydrofuran / 1.) r.t., 30 min, 2.) 55 deg C, 20.5 h

3: H₂ / 10percent Pd/C / methanol / 2 h

With hydrogen; sodium hydrogencarbonate; palladium on activated charcoal; In tetrahydrofuran; methanol; water;
DOI:10.1021/jo00092a022

Reference yield:

: 13504-85-3
(2S,4R)-1-(benzyloxycarbonyl)-4-hydroxypyrrolidine-2-carboxylic acid

: 393154-87-5
ert-butyl 4-hydroxypyrrolidine-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: tetrahydrofuran / 1.) r.t., 30 min, 2.) 55 deg C, 20.5 h

2: H₂ / 10percent Pd/C / methanol / 2 h

With hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol;
DOI:10.1021/jo00092a022