7-BROMO-5-NITROINDOLINE

Base Information

• Chemical Name: 7-BROMO-5-NITROINDOLINE
• CAS No.: 87240-06-0
• Molecular Formula: C8H7BrN2O2
• Molecular Weight: 243.06
• Hs Code.: 2933990090
• Mol file: 87240-06-0.mol

Synonyms:7-bromo-5-nitro-2,3-dihydro-1H-indole;

Chemical Property of 7-BROMO-5-NITROINDOLINE

Chemical Property:

• Vapor Pressure: 3.01E-05mmHg at 25°C
• Melting Point: 149-151℃
• Boiling Point: 356°C at 760 mmHg
• PKA: -1.03±0.20(Predicted)
• Flash Point: 169.1°C
• PSA: 57.85000
• Density: 1.704g/cm³
• LogP: 2.98650
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

98%min ^*data from raw suppliers

7-Bromo-5-nitroindoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 7-BROMO-5-NITROINDOLINE

There total 3 articles about 7-BROMO-5-NITROINDOLINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

5-nitro-2,3-dihydro-1H-indole (32692-19-6) → 7-bromo-5-nitroindoline (87240-06-0)

Guidance literature:

With bromine; In acetic acid;

Reference yield:

1-Acetyl-2,3-dihydro-1H-indole (16078-30-1) → 7-bromo-5-nitroindoline (87240-06-0)

Guidance literature:

Multi-step reaction with 3 steps

1: concentrated sulfuric acid; nitric acid / 20 °C

2: aq.-ethanolic hydrochloric acid

3: acetic acid; bromine

With hydrogenchloride; sulfuric acid; bromine; nitric acid; acetic acid;

DOI:10.1021/jo01128a012

Reference yield:

1-(5-nitro-2,3-dihydroindol-1-yl)ethanone (33632-27-8) → 7-bromo-5-nitroindoline (87240-06-0)

Guidance literature:

Multi-step reaction with 2 steps

1: aq.-ethanolic hydrochloric acid

2: acetic acid; bromine

With hydrogenchloride; bromine; acetic acid;

DOI:10.1021/jo01128a012

upstream raw materials:

5-nitro-2,3-dihydro-1H-indole

1-Acetyl-2,3-dihydro-1H-indole

1-(5-nitro-2,3-dihydroindol-1-yl)ethanone

Downstream raw materials:

1-acetyl-7-bromo-5-nitro-indoline

7-bromo-5-nitro-1H-indole

hippadine

anhydrolycorine-7-one

Refernces

• 1、 -. "NOVEL COMPOUNDS AS DIACYLGLYCEROL ACYLTRANSFERASE INHIBITORS". Page/Page column 50. . Retrieved 2014/06/11.
• 2、 -. "5- AND 6-(2-IMIDAZOLIN-2-YLAMINO) AND -(2-THIAZOLIN-2-YLAMINO)-BENZOTHIAZOLES AS ALPHA-2 ADRENERGIC LIGANDS". . . Retrieved 2008/06/13.