Acetic acid, [4-[12-(butylmethylamino)-1-[3-(1-methylethyl)-4-[[tris(1-methylethyl)silyl] oxy]phenyl]-12-oxo-4-dodecenyl]-3,5-dimethylphenoxy]-, methyl ester

Base Information

Chemical Name:Acetic acid, [4-[12-(butylmethylamino)-1-[3-(1-methylethyl)-4-[[tris(1-methylethyl)silyl] oxy]phenyl]-12-oxo-4-dodecenyl]-3,5-dimethylphenoxy]-, methyl ester
CAS No.:393836-16-3
Molecular Formula:C46H75NO5Si
Molecular Weight:750.191
Hs Code.:

Acetic acid,
[4-[12-(butylmethylamino)-1-[3-(1-methylethyl)-4-[[tris(1-methylethyl)silyl]
oxy]phenyl]-12-oxo-4-dodecenyl]-3,5-dimethylphenoxy]-, methyl ester

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Chemical Property of Acetic acid, [4-[12-(butylmethylamino)-1-[3-(1-methylethyl)-4-[[tris(1-methylethyl)silyl] oxy]phenyl]-12-oxo-4-dodecenyl]-3,5-dimethylphenoxy]-, methyl ester

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Technology Process of Acetic acid, [4-[12-(butylmethylamino)-1-[3-(1-methylethyl)-4-[[tris(1-methylethyl)silyl] oxy]phenyl]-12-oxo-4-dodecenyl]-3,5-dimethylphenoxy]-, methyl ester

There total 17 articles about Acetic acid, [4-[12-(butylmethylamino)-1-[3-(1-methylethyl)-4-[[tris(1-methylethyl)silyl] oxy]phenyl]-12-oxo-4-dodecenyl]-3,5-dimethylphenoxy]-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 13.0%

: 134414-26-9
N-butyl-N-methyl-8-bromooctanamide

: 253329-15-6
{4-[1-(3-isopropyl-4-triisopropylsilanyloxy-phenyl)-4-oxo-butyl]-3,5-dimethyl-phenoxy}-acetic acid methyl ester

: 393836-16-3
{4-[(Z)-11-(Butyl-methyl-carbamoyl)-1-(3-isopropyl-4-triisopropylsilanyloxy-phenyl)-undec-4-enyl]-3,5-dimethyl-phenoxy}-acetic acid methyl ester

Guidance literature:: N-butyl-N-methyl-8-bromooctanamide; With triphenylphosphine; at 125 ℃; for 22h;

{4-[1-(3-isopropyl-4-triisopropylsilanyloxy-phenyl)-4-oxo-butyl]-3,5-dimethyl-phenoxy}-acetic acid methyl ester; With potassium tert-butylate; In tetrahydrofuran; for 7h; Heating / reflux;

Reference yield:

: 110-68-9
N-n-butyl-N-methylamine

: 393836-16-3
{4-[(Z)-11-(Butyl-methyl-carbamoyl)-1-(3-isopropyl-4-triisopropylsilanyloxy-phenyl)-undec-4-enyl]-3,5-dimethyl-phenoxy}-acetic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: 77 percent / HBTU; Et₃N / CH₂Cl₂

2.1: 125 °C

3.1: LiHMDS / tetrahydrofuran

3.2: tetrahydrofuran

With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane;
DOI:10.1016/S0960-894X(01)00521-2

Reference yield:

: 88-69-7
2-(1-methylethyl)phenol

: 393836-16-3
{4-[(Z)-11-(Butyl-methyl-carbamoyl)-1-(3-isopropyl-4-triisopropylsilanyloxy-phenyl)-undec-4-enyl]-3,5-dimethyl-phenoxy}-acetic acid methyl ester

Guidance literature:: Multi-step reaction with 10 steps

1.1: 63 percent / Br₂ / CH₂Cl₂

2.1: 72 percent / imidazole / 1,2-dichloro-ethane

3.1: n-BuLi / tetrahydrofuran / -78 °C

3.2: CeCl₃ / tetrahydrofuran / -78 °C

3.3: tetrahydrofuran / -78 °C

4.1: TFA / CH₂Cl₂ / -45 °C

5.1: 85 percent / Et₃N*3HF / tetrahydrofuran

6.1: 100 percent / Cs₂CO₃ / dimethylformamide

7.1: 80 percent / TFA / CH₂Cl₂ / -45 °C

8.1: 9-BBN / tetrahydrofuran

8.2: 88 percent / H₂O₂; NaOH

9.1: 65 percent / PDC / CH₂Cl₂

10.1: LiHMDS / tetrahydrofuran

10.2: tetrahydrofuran

With 1H-imidazole; dipyridinium dichromate; 9-borabicyclo[3.3.1]nonane dimer; n-butyllithium; bromine; caesium carbonate; triethylamine tris(hydrogen fluoride); trifluoroacetic acid; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(01)00521-2