(4R)-4-{[(2S)-2-(acetylamino)-3-carboxypropanoyl]amino}-5-{[(2S,3S)-1-({(2S)-1-[(2S,4R)-4-(benzyloxy)-2-{[2-(2,3-dihydro-1H-indol-1-ylcarbonyl)-2-propylhydrazinyl]carbonyl}pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl}amino)-3-methyl-1-oxopentan-2-yl]amino}-5

Base Information

• Chemical Name: (4R)-4-{[(2S)-2-(acetylamino)-3-carboxypropanoyl]amino}-5-{[(2S,3S)-1-({(2S)-1-[(2S,4R)-4-(benzyloxy)-2-{[2-(2,3-dihydro-1H-indol-1-ylcarbonyl)-2-propylhydrazinyl]carbonyl}pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl}amino)-3-methyl-1-oxopentan-2-yl]amino}-5
• CAS No.: 220440-84-6
• Molecular Formula: C₄₆H₆₄N₈O₁₂
• Molecular Weight: 921.061

Synonyms:

Chemical Property of (4R)-4-{[(2S)-2-(acetylamino)-3-carboxypropanoyl]amino}-5-{[(2S,3S)-1-({(2S)-1-[(2S,4R)-4-(benzyloxy)-2-{[2-(2,3-dihydro-1H-indol-1-ylcarbonyl)-2-propylhydrazinyl]carbonyl}pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl}amino)-3-methyl-1-oxopentan-2-yl]amino}-5

Chemical Property:

• Density: 1.33g/cm³

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Technology Process of (4R)-4-{[(2S)-2-(acetylamino)-3-carboxypropanoyl]amino}-5-{[(2S,3S)-1-({(2S)-1-[(2S,4R)-4-(benzyloxy)-2-{[2-(2,3-dihydro-1H-indol-1-ylcarbonyl)-2-propylhydrazinyl]carbonyl}pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl}amino)-3-methyl-1-oxopentan-2-yl]amino}-5

There total 3 articles about (4R)-4-{[(2S)-2-(acetylamino)-3-carboxypropanoyl]amino}-5-{[(2S,3S)-1-({(2S)-1-[(2S,4R)-4-(benzyloxy)-2-{[2-(2,3-dihydro-1H-indol-1-ylcarbonyl)-2-propylhydrazinyl]carbonyl}pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl}amino)-3-methyl-1-oxopentan-2-yl]amino}-5 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(2-acetylamino-3-benzyloxycarbonyl-propionylamino)-4-[1-(1-{4-benzyloxy-2-[N'-(2,3-dihydro-indole-1-carbonyl)-N'-propyl-hydrazinocarbonyl]-pyrrolidine-1-carbonyl}-2-methyl-propylcarbamoyl)-2-methyl-butylcarbamoyl]-butyric acid benzyl ester → (R)-4-((S)-2-Acetylamino-3-carboxy-propionylamino)-4-[(1S,2S)-1-((S)-1-{(2S,4R)-4-benzyloxy-2-[N'-(2,3-dihydro-indole-1-carbonyl)-N'-propyl-hydrazinocarbonyl]-pyrrolidine-1-carbonyl}-2-methyl-propylcarbamoyl)-2-methyl-butylcarbamoyl]-butyric acid (220440-84-6)

Guidance literature:

With ammonium acetate; hydrogen; palladium on activated charcoal; In ethanol;

DOI:10.1021/jm049864b

Reference yield:

2,3-dihydro-indole-1-carboxylic acid N-propyl-hydrazide → (R)-4-((S)-2-Acetylamino-3-carboxy-propionylamino)-4-[(1S,2S)-1-((S)-1-{(2S,4R)-4-benzyloxy-2-[N'-(2,3-dihydro-indole-1-carbonyl)-N'-propyl-hydrazinocarbonyl]-pyrrolidine-1-carbonyl}-2-methyl-propylcarbamoyl)-2-methyl-butylcarbamoyl]-butyric acid (220440-84-6)

Guidance literature:

Multi-step reaction with 2 steps

1: TBTU; iPr₂NEt / dimethylformamide / 20 °C

2: 4 mg / H₂; NH₄OAc / Pd/C / ethanol

With ammonium acetate; hydrogen; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide;

DOI:10.1021/jm049864b

Reference yield:

(2S,4R)-1-((S)-2-{(2S,3S)-2-[(R)-2-((S)-2-Acetylamino-3-benzyloxycarbonyl-propionylamino)-4-benzyloxycarbonyl-butyrylamino]-3-methyl-pentanoylamino}-3-methyl-butyryl)-4-benzyloxy-pyrrolidine-2-carboxylic acid → (R)-4-((S)-2-Acetylamino-3-carboxy-propionylamino)-4-[(1S,2S)-1-((S)-1-{(2S,4R)-4-benzyloxy-2-[N'-(2,3-dihydro-indole-1-carbonyl)-N'-propyl-hydrazinocarbonyl]-pyrrolidine-1-carbonyl}-2-methyl-propylcarbamoyl)-2-methyl-butylcarbamoyl]-butyric acid (220440-84-6)

Guidance literature:

Multi-step reaction with 2 steps

1: TBTU; iPr₂NEt / dimethylformamide / 20 °C

2: 4 mg / H₂; NH₄OAc / Pd/C / ethanol

With ammonium acetate; hydrogen; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide;

DOI:10.1021/jm049864b

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