5-Fluoro-2-nitrobenzoyl chloride

Base Information

• Chemical Name: 5-Fluoro-2-nitrobenzoyl chloride
• CAS No.: 394-02-5
• Molecular Formula: C7H3ClFNO3
• Molecular Weight: 203.557
• Hs Code.: 2916399090
• Mol file: 394-02-5.mol

Synonyms:5-fluoro-2-nitro-benzoyl chloride;2-nitro-5-fluorobenzamide;5-Fluor-2-nitro-benzoylchlorid;5-fluoro-2-nitro-1-benzenecarbonyl chloride;5-fluoro-2-nitro-benzamide;Benzamide,5-fluoro-2-nitro;5-Fluor-2-nitro-benzoesaeurechlorid;

Chemical Property of 5-Fluoro-2-nitrobenzoyl chloride

Chemical Property:

• PSA: 62.89000
• LogP: 2.63610
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

5-Fluoro-2-nitrobenzoyl chloride 95.0% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Fluoro-2-nitrobenzoyl chloride

There total 3 articles about 5-Fluoro-2-nitrobenzoyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-fluoro-2-nitrobenzoic acid (320-98-9) → 5-fluoro-2-nitrobenzoyl chloride (394-02-5)

Guidance literature:

With thionyl chloride;

DOI:10.1021/ja01235a032

Reference yield:

3-fluorobenzoic acid (455-38-9) → 5-fluoro-2-nitrobenzoyl chloride (394-02-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 91 percent / H₂SO₄, HNO₃ / 0 °C

2: oxalyl chloride / dimethylformamide

With oxalyl dichloride; sulfuric acid; nitric acid; In N,N-dimethyl-formamide;

DOI:10.1016/S0040-4039(00)80691-7

Reference yield:

→ 5-fluoro-2-nitrobenzoyl chloride (394-02-5)

Guidance literature:

14;

upstream raw materials:

5-fluoro-2-nitrobenzoic acid

3-fluorobenzoic acid

Downstream raw materials:

methyl 5-fluoro-2-nitrobenzoate

5-fluoro-2-nitro-benzoic acid propyl ester

5-fluoro-2-nitro-benzoic acid-(2-dimethylamino-ethyl ester); hydrochloride

ethyl 5-fluoro-2-nitrobenzoate