benzyl N-(2-chloroacetyl)carbamate

Base Information

Chemical Name:benzyl N-(2-chloroacetyl)carbamate
CAS No.:16001-64-2
Molecular Formula:C₁₀H₁₀ClNO₃
Molecular Weight:227.647
Hs Code.:2924299090
DSSTox Substance ID:DTXSID00427910
Wikidata:Q82240652
Mol file:16001-64-2.mol

Synonyms:benzyl N-(2-chloroacetyl)carbamate;16001-64-2;benzyl chloroacetylcarbamate;Benzyl (2-chloroacetyl)carbamate;Carbamic acid, N-(2-chloroacetyl)-, phenylmethyl ester;Benzyl(2-chloroacetyl)carbamate;SCHEMBL11071727;DTXSID00427910;AKOS000118404;PD193135;CS-0234920;EN300-14987;Z107334158

Suppliers and Price of benzyl N-(2-chloroacetyl)carbamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
BenzylN-(2-Chloroacetyl)carbamate
50mg
$ 90.00

American Custom Chemicals Corporation
BENZYL CHLOROACETYLCARBAMATE 95.00%
5G
$ 1168.42

American Custom Chemicals Corporation
BENZYL CHLOROACETYLCARBAMATE 95.00%
2.5G
$ 983.88

American Custom Chemicals Corporation
BENZYL CHLOROACETYLCARBAMATE 95.00%
1G
$ 721.57

Total 4 raw suppliers

Chemical Property of benzyl N-(2-chloroacetyl)carbamate

Chemical Property:

Boiling Point:°Cat760mmHg
Flash Point:°C
PSA：58.89000
Density:1.292g/cm³
LogP:2.51850
XLogP3:1.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:227.0349209
Heavy Atom Count:15
Complexity:227

Purity/Quality:

99% ^*data from raw suppliers

BenzylN-(2-Chloroacetyl)carbamate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C(C=C1)COC(=O)NC(=O)CCl

Technology Process of benzyl N-(2-chloroacetyl)carbamate

There total 1 articles about benzyl N-(2-chloroacetyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 16001-64-2
benzyl 2-chloroacetylcarbamate

Guidance literature:: Benzylcarbamat, ClCH2-COCl;
DOI:10.1002/jsfa.2740180206

Reference yield: 76.0%

: 16001-64-2
benzyl 2-chloroacetylcarbamate

: 603-35-0
triphenylphosphine

: 1379586-18-1
(2-(benzyloxycarbonylamino)-2-oxoethyl)triphenyl-phosphonium chloride

Guidance literature:: In tetrahydrofuran; Reflux;
DOI:10.1039/c2ob25122a

Reference yield:

: 16001-64-2
benzyl 2-chloroacetylcarbamate

: benzyl 4-(tert-butyldiphenylsilyloxy)-3-( phenylamino)-butanoylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1: tetrahydrofuran / Reflux

2: potassium tert-butylate / tetrahydrofuran / 1 h / -5 °C

3: dichloromethane / 16 h

4: [(R)-(+)-2,2'-bis(diphenylphosphino)-1,1'-binaphthyl]-diaquo-palladium(II) bis(triflate) / toluene / 38 h / 50 °C / Inert atmosphere

With [(R)-(+)-2,2'-bis(diphenylphosphino)-1,1'-binaphthyl]-diaquo-palladium(II) bis(triflate); potassium tert-butylate; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1039/c2ob25122a