4-Morpholinobutanoic acid hydrochloride

Base Information

• Chemical Name: 4-Morpholinobutanoic acid hydrochloride
• CAS No.: 39493-84-0
• Molecular Formula: C8H15NO3.ClH
• Molecular Weight: 209.673
• Hs Code.: 2934999090
• DSSTox Substance ID: DTXSID20508437
• Mol file: 39493-84-0.mol

Synonyms:39493-84-0;4-Morpholinobutanoic acid hydrochloride;4-(4-Morpholinyl)butanoic acid hydrochloride;4-Morpholinebutanoic acid HCl;Morpholin-4-ylbutanoic acid hydrochloride;4-morpholin-4-ylbutanoic acid;hydrochloride;4-MORPHOLIN-4-YL-BUTYRIC ACID HYDROCHLORIDE;4-(Morpholin-4-Yl)Butanoic Acid Hydrochloride;SCHEMBL1127696;DTXSID20508437;TQP0307;GQWYWIYUQZVZAV-UHFFFAOYSA-N;4-morpholinobutanoic acid HCl salt;MFCD06801119;4-morpholinobutyric acid hydrochloride;AKOS016010328;gamma-morpholinobutyric acid hydrochloride;BS-37515;gamma-morpholino-butyric acid hydrochloride;CS-0313001;gamma-morpholinobutyric acid, hydrochloride salt;EN300-7369453;4-(4-Morpholinyl)butanoic acid hydrochloride, AldrichCPR;4-(Morpholin-4-yl)butanoic acid--hydrogen chloride (1/1)

Chemical Property of 4-Morpholinobutanoic acid hydrochloride

Chemical Property:

• Melting Point: 131-133 °C
• PSA: 49.77000
• LogP: 0.92330
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 209.0818711
• Heavy Atom Count: 13
• Complexity: 143

Purity/Quality:

98%min ^*data from raw suppliers

4-MorpholinebutanoicAcidHydrochloride ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26

MSDS Files:

Useful:

• Canonical SMILES: C1COCCN1CCCC(=O)O.Cl

Technology Process of 4-Morpholinobutanoic acid hydrochloride

There total 3 articles about 4-Morpholinobutanoic acid hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3-morpholin-4-ylpropionic acid ethyl ester (88217-57-6) → γ-morpholino-butyric acid hydrochloride (39493-84-0)

Guidance literature:

With hydrogenchloride; In water; for 18h; Reflux;

DOI:10.1016/j.tet.2011.12.030

Reference yield: 53.0%

morpholine (110-91-8,99108-56-2) + Ethyl 4-bromobutyrate (2969-81-5) → γ-morpholino-butyric acid hydrochloride (39493-84-0)

Guidance literature:

morpholine; Ethyl 4-bromobutyrate; In toluene; at 20 - 60 ℃;

With hydrogenchloride; In water; for 16h; Heating / reflux;

Reference yield:

→ γ-morpholino-butyric acid hydrochloride (39493-84-0)

Guidance literature:

upstream raw materials:

3-morpholin-4-ylpropionic acid ethyl ester

morpholine

Ethyl 4-bromobutyrate

Downstream raw materials:

3-(4-morpholinobutanamido)benzoic acid

benzyl 3-(4-morpholinobutanamido)benzoate

4-(4-morpholinobutanamido)benzoic acid

benzyl 4-(4-morpholinobutanamido)benzoate

Refernces

• 1、 May, Jonathan P.,Undzys, Elijus,Roy, Aniruddha,Li, Shyh-Dar. "Synthesis of a Gemcitabine Prodrug for Remote Loading into Liposomes and Improved Therapeutic Effect". . p. 226 - 237. Retrieved 2016/02/05.
• 2、 -. "2-CARBOCYCLOAMINO-4-IMIDAZ0LYLPYRIMIDINES AS AGENTS FOR THE INHBITION OF CELL PROLIFERATION". Page/Page column 55. . Retrieved 2008/06/13.