14-Oxa-2,5,12-triazahexadecanoic acid, 15,15-dimethyl-4,13-dioxo-3-[[4-(4-pyridinylmethoxy)phenyl]methyl]-, 9H-fluoren-9-ylmethyl ester, (3S)-

Base Information

Chemical Name:14-Oxa-2,5,12-triazahexadecanoic acid, 15,15-dimethyl-4,13-dioxo-3-[[4-(4-pyridinylmethoxy)phenyl]methyl]-, 9H-fluoren-9-ylmethyl ester, (3S)-
CAS No.:395063-09-9
Molecular Formula:C41H48N4O6
Molecular Weight:692.855
Hs Code.:

14-Oxa-2,5,12-triazahexadecanoic acid,
15,15-dimethyl-4,13-dioxo-3-[[4-(4-pyridinylmethoxy)phenyl]methyl]-,
9H-fluoren-9-ylmethyl ester, (3S)-

Synonyms:

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Chemical Property of 14-Oxa-2,5,12-triazahexadecanoic acid, 15,15-dimethyl-4,13-dioxo-3-[[4-(4-pyridinylmethoxy)phenyl]methyl]-, 9H-fluoren-9-ylmethyl ester, (3S)-

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Technology Process of 14-Oxa-2,5,12-triazahexadecanoic acid, 15,15-dimethyl-4,13-dioxo-3-[[4-(4-pyridinylmethoxy)phenyl]methyl]-, 9H-fluoren-9-ylmethyl ester, (3S)-

There total 1 articles about 14-Oxa-2,5,12-triazahexadecanoic acid, 15,15-dimethyl-4,13-dioxo-3-[[4-(4-pyridinylmethoxy)phenyl]methyl]-, 9H-fluoren-9-ylmethyl ester, (3S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.7%

: 51857-17-1
tert-butyl N-(6-aminohexyl)carbamate

: 325464-34-4
Fmoc-Tyr(O-Pic)-OH

: 395063-09-9
Fmoc-Tyr(O-Pic)-NH-(CH₂)6-NH-Boc

Guidance literature:: With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1248/cpb.49.1457

Reference yield:

: 395063-09-9
Fmoc-Tyr(O-Pic)-NH-(CH₂)6-NH-Boc

: 1027162-01-1
H-Tyr(O-Pic)-NH-(CH₂)6-NH-Boc

Guidance literature:: With piperidine; In N,N-dimethyl-formamide; at 20 ℃; for 1.5h;
DOI:10.1248/cpb.49.1457

Reference yield:

: 395063-09-9
Fmoc-Tyr(O-Pic)-NH-(CH₂)6-NH-Boc

: 395063-13-5
(6-{2-{[4-(tert-butoxycarbonylamino-methyl)-cyclohexanecarbonyl]-amino}-3-[4-(pyridin-4-ylmethoxy)-phenyl]-propionylamino}-hexyl)-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: piperidine / dimethylformamide / 1.5 h / 20 °C

2: 77 percent / BOP; HOBt; DIPEA / dimethylformamide / 20 °C

With piperidine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide;
DOI:10.1248/cpb.49.1457