3-PHENYL-PYRIDAZINE

Base Information

• Chemical Name: 3-PHENYL-PYRIDAZINE
• CAS No.: 15150-84-2
• Molecular Formula: C10H8N2
• Molecular Weight: 156.187
• Hs Code.: 2933990090
• Mol file: 15150-84-2.mol

Synonyms:TCMDC-123929;

Chemical Property of 3-PHENYL-PYRIDAZINE

Chemical Property:

• Vapor Pressure: 0.000105mmHg at 25°C
• Melting Point: 98 °C
• Refractive Index: 1.58
• Boiling Point: 347.9 °C at 760 mmHg
• PKA: 2.52±0.10(Predicted)
• Flash Point: 166.2 °C
• PSA: 25.78000
• Density: 1.106 g/cm³
• LogP: 2.14360
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

3-Phenylpyridazine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-PHENYL-PYRIDAZINE

There total 35 articles about 3-PHENYL-PYRIDAZINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

1-(3-phenylpyridazin-1(6H)-yl)ethan-1-one → 3-phenylpyridazine (15150-84-2)

Guidance literature:

With sodium hydroxide; In acetonitrile; at 90 ℃; for 1h;

DOI:10.1021/acs.orglett.8b01240

Reference yield: 95.0%

ethyl 4-chloro-6-ethoxy-5,6-dihydro-3-phenyl-1(4H)pyridazinecarboxylate → 3-phenylpyridazine (15150-84-2)

Guidance literature:

With potassium hydroxide; In ethanol; for 4h; Heating;

DOI:10.1021/jo960029e

Reference yield: 95.0%

ethyl 4-chloro-6-ethoxy-5,6-dihydro-3-phenyl-1(4H)pyridazinecarboxylate → 3-phenylpyridazine (15150-84-2)

Guidance literature:

With potassium hydroxide; In ethanol; for 4h; Heating;

DOI:10.1021/jo960029e

upstream raw materials:

1,2-diazine

phenyllithium

3-chloro-6-phenylpyradazine

6-phenyl-3(2H)-pyridazinethione

Downstream raw materials:

3-phenyl-hexahydro-pyridazine

3-phenylpyridazine 1-oxide

1-methoxy-3-phenylpyridazin-1-ium methyl sulfate

2-methyl-7-phenyl-1H-indole

Refernces

• 1、 Wang, Shengqiang,Lu, Hongtao,Li, Jingya,Zou, Dapeng,Wu, Yusheng,Wu, Yangjie. "Synthesis of functionalized 3-arylpyridazines via Pd-catalyzed decarboxylative cross-coupling of pyridazine-3-carboxylic acids". . p. 1107 - 1111. Retrieved 2017.
• 2、 Balkenhohl, Moritz,Jangra, Harish,Lenz, Tobias,Ebeling, Marian,Zipse, Hendrik,Karaghiosoff, Konstantin,Knochel, Paul. "Lewis Acid Directed Regioselective Metalations of Pyridazine". supporting information. p. 9244 - 9247. Retrieved 2019/06/04.