3,5-Dioxo-piperidine-1-carboxylicacidtert-butylester

Base Information

• Chemical Name: 3,5-Dioxo-piperidine-1-carboxylicacidtert-butylester
• CAS No.: 396731-40-1
• Molecular Formula: C10H15NO4
• Molecular Weight: 213.233
• Hs Code.: 2933399090
• Mol file: 396731-40-1.mol

Synonyms:1,1-dimethylethyl 3,5-dioxo-1-piperidinecarboxylate;1-[(1,1-dimethylethoxy)carbonyl]-3,5-dioxopiperidine;

Chemical Property of 3,5-Dioxo-piperidine-1-carboxylicacidtert-butylester

Chemical Property:

• Boiling Point: 346.2±32.0 °C(Predicted)
• PKA: 9.72±0.20(Predicted)
• PSA: 63.68000
• Density: 1.199±0.06 g/cm3(Predicted)
• LogP: 0.70330
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl3,5-dioxopiperidine-1-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3,5-Dioxo-piperidine-1-carboxylicacidtert-butylester can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process.

Technology Process of 3,5-Dioxo-piperidine-1-carboxylicacidtert-butylester

There total 1 articles about 3,5-Dioxo-piperidine-1-carboxylicacidtert-butylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

ethyl 2-(tert-butoxycarbonyl(2-oxopropyl)amino)acetate (873190-14-8) → tert-butyl 3,5-dioxopiperidine- 1-carboxylate (396731-40-1)

Guidance literature:

With potassium tert-butylate; In diethyl ether; at 5 ℃; for 4.5h;

Reference yield: 75.0%

tert-butyl 3,5-dioxopiperidine- 1-carboxylate (396731-40-1) + toluene-4-sulfonic acid hydrazide (1576-35-8) → tert-butyl 5-[(4-methylphenyl)hydrazinesulfonyl]-3-oxo-1,2,3,6-tetrahydropyridine-1-carboxylate

Guidance literature:

With acetic acid; In water; at 0 - 25 ℃; for 48h; Inert atmosphere;

Reference yield: 54.0%

tert-butyl 3,5-dioxopiperidine- 1-carboxylate (396731-40-1) + phenyl isothiocyanate (103-72-0) → tert-butyl 5-hydroxy-3-oxo-4-(phenylcarbamothioyl)-3,6-dihydropyridine-1(2H)-carboxylate

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile; at 0 - 20 ℃; for 16h;

upstream raw materials:

ethyl 2-(tert-butoxycarbonyl(2-oxopropyl)amino)acetate

Downstream raw materials:

tert-butyl 2-amino-7-oxo-6,7-dihydro-4H-thiazolo[4,5-c]pyridine-5-carboxylate

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