N-phenyl-2-thiophenesulfonamide

Base Information

• Chemical Name: N-phenyl-2-thiophenesulfonamide
• CAS No.: 39810-46-3
• Molecular Formula: C10H9NO2S2
• Molecular Weight: 239.319
• Mol file: 39810-46-3.mol

Synonyms:2-Thiophensulfonylanilid;N-phenyl-2-thienylsulfonamide;thiophene-2-sulfonic acid phenylamide;2-Thiophensulfonanilid;Thiophen-2-sulfonsaeure-anilid;thiophene-2-sulfonic acid anilide;N-phenyl-2-thiophenesulfonamide;

Chemical Property of N-phenyl-2-thiophenesulfonamide

Chemical Property:

• PSA: 82.79000
• LogP: 3.70270

Purity/Quality:

N-PHENYL-2-THIOPHENESULFONAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-phenyl-2-thiophenesulfonamide

There total 9 articles about N-phenyl-2-thiophenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

thiophene boronic acid (6165-68-0) + nitrobenzene (98-95-3,26969-40-4) → N-phenyl-S-2-thiophenylsulfonamide (39810-46-3)

Guidance literature:

With potassium pyrosulfite; tetrabutyl-ammonium chloride; potassium carbonate; In acetonitrile; at 130 ℃; for 24h; Sealed tube;

DOI:10.1021/acs.orglett.0c00183

Reference yield: 94.0%

sodium thiophene-2-sulphinate (38945-01-6) + nitrobenzene (98-95-3,26969-40-4) → N-phenyl-S-2-thiophenylsulfonamide (39810-46-3)

Guidance literature:

With trans-N,N'-dimethyl-1,2-cyclohexyldiamine; sodium hydrogen sulfite; iron(II) chloride; In dimethyl sulfoxide; at 60 ℃; for 12h; Sealed tube; Inert atmosphere;

DOI:10.1021/acs.joc.5b00130

Reference yield: 88.0%

thiophene-2-sulfonyl chloride (16629-19-9) + nitrobenzene (98-95-3,26969-40-4) → N-phenyl-S-2-thiophenylsulfonamide (39810-46-3)

Guidance literature:

With iron; In water; for 0.833333h;

upstream raw materials:

thiophene-2-sulfonyl chloride

aniline

thiophene-2-sulfonyl fluoride

Diphenyliodonium triflate

Downstream raw materials:

N-(1-allyl-5-methyl-1H-indol-2-yl)-N-(2-iodophenyl)thiophene-2-sulfonamide

5-(4-nitrophenyl)thiophene-2-sulfonic acid phenylamide