Tazolol

Base Information

• Chemical Name: Tazolol
• CAS No.: 39832-48-9
• Deprecated CAS: 41731-89-9
• Molecular Formula: C9H16N2O2S
• Molecular Weight: 216.30100
• UNII: B64Q38TX4G
• DSSTox Substance ID: DTXSID80865972
• Nikkaji Number: J446.393E
• Wikipedia: Tazolol
• Wikidata: Q7690466
• NCI Thesaurus Code: C81660
• ChEMBL ID: CHEMBL2111158
• Mol file: 39832-48-9.mol

Synonyms:1-isopropylamino-3-(2-thiazoloxy)-2-propanol;H110-38;tazolol

Chemical Property of Tazolol

Chemical Property:

• Vapor Pressure: 1.89E-05mmHg at 25°C
• Boiling Point: 348.4oC at 760 mmHg
• Flash Point: 164.5oC
• PSA: 82.62000
• Density: 1.164g/cm3
• LogP: 1.27170
• XLogP3: 1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 6
• Exact Mass: 216.09324893
• Heavy Atom Count: 14
• Complexity: 158

Purity/Quality:

99% ^*data from raw suppliers

TAZOLOL 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)NCC(COC1=NC=CS1)O

Technology Process of Tazolol

There total 5 articles about Tazolol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(2,2-dimethyl-[1,3]dioxolan-4-ylmethoxy)-thiazole (39832-49-0) → (+/-)-Tazolol (39832-48-9)

Guidance literature:

Multi-step reaction with 3 steps

1: aq. HCl / H₂O / 2 h / (heating)

2: (i) MeSO₂Cl, Py, (ii) NaOMe, Et₂O

3: 1 h / 80 °C

With hydrogenchloride; In water;

DOI:10.1021/jm00248a012

Reference yield:

1-(thiazol-2-yloxy)-2,3-epoxypropane (39832-47-8) + isopropylamine (75-31-0) → (+/-)-Tazolol (39832-48-9)

Guidance literature:

at 80 ℃; for 1h;

DOI:10.1021/jm00248a012

Reference yield:

3-thiazol-2-yloxy-propane-1,2-diol (39832-45-6) → (+/-)-Tazolol (39832-48-9)

Guidance literature:

Multi-step reaction with 2 steps

1: (i) MeSO₂Cl, Py, (ii) NaOMe, Et₂O

2: 1 h / 80 °C

DOI:10.1021/jm00248a012

upstream raw materials:

2-bromo-1,3-thiazole

oxiranyl-methanol

isopropylamine

1-(thiazol-2-yloxy)-2,3-epoxypropane

Refernces

• 1、 -. "THIAZOLE CARDIOVASCULAR AGENTS". . . Retrieved 2008/06/13.