Benzamide, 2-chloro-N-(2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)-

Base Information

• Chemical Name: Benzamide, 2-chloro-N-(2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)-
• CAS No.: 3985-30-6
• Molecular Formula: C₁₈H₁₆ClN₃O₂
• Molecular Weight: 341.797
• Mol file: 3985-30-6.mol

Synonyms:4-(2-chloro-benzoylamino)-1,5-dimethyl-2-phenyl-1,2-dihydro-pyrazol-3-one;2-Chloro-N-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-benzamide;4-(2-Chlor-benzoylamino)antipyrin;

Chemical Property of Benzamide, 2-chloro-N-(2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)-

Chemical Property:

• Melting Point: 103 - 104 °C (ethanol)
• PSA: 56.03000
• LogP: 3.46310

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzamide, 2-chloro-N-(2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)-

There total 3 articles about Benzamide, 2-chloro-N-(2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

4-amino-2,3-dimethyl-1-phenylpyrazolin-5-one (83-07-8) + o-chlorobenzoyl chloride (609-65-4) → 2-chloro-N-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)benzamide (3985-30-6)

Guidance literature:

With pyridine; for 3h; Reflux;

DOI:10.1039/c5ra17568b

Reference yield:

ortho-chlorobenzoic acid (118-91-2) → 2-chloro-N-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)benzamide (3985-30-6)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride / 2 h / Reflux

2: pyridine / 3 h / Reflux

With pyridine; thionyl chloride;

DOI:10.1039/c5ra17568b

Reference yield:

→ 2-chloro-N-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)benzamide (3985-30-6)

Guidance literature:

4-Amino-antipyrin, 2-Chlorbenzoesaeure/PCl3/Benzol;

DOI:10.1007/BF00778058

upstream raw materials:

ortho-chlorobenzoic acid

4-amino-2,3-dimethyl-1-phenylpyrazolin-5-one

o-chlorobenzoyl chloride