1-(3-CHLOROPHENYL)PROPAN-1-AMINE

Base Information

• Chemical Name: 1-(3-CHLOROPHENYL)PROPAN-1-AMINE
• CAS No.: 40023-86-7
• Molecular Formula: C9H12ClN
• Molecular Weight: 169.654
• Hs Code.: 2921499090
• Mol file: 40023-86-7.mol

Synonyms:

Chemical Property of 1-(3-CHLOROPHENYL)PROPAN-1-AMINE

Chemical Property:

• Vapor Pressure: 0.051mmHg at 25°C
• Boiling Point: 234.965oC at 760 mmHg
• Flash Point: 108.883oC
• PSA: 26.02000
• Density: 1.094g/cm3
• LogP: 3.45010

Purity/Quality:

98%min ^*data from raw suppliers

1-(3-chlorophenyl)propan-1-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(3-CHLOROPHENYL)PROPAN-1-AMINE

There total 6 articles about 1-(3-CHLOROPHENYL)PROPAN-1-AMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

ethylmagnesium bromide (925-90-6) + m-Chlorobenzaldehyde (587-04-2) → 1-(3-chlorophenyl)propylamine (40023-86-7,1075715-57-9,1168139-52-3)

Guidance literature:

With ammonium chloride; lithium hexamethyldisilazane; In tetrahydrofuran; diethyl ether; at 20 ℃; for 24h; Heating / reflux;

Reference yield: 66.0%

ethylmagnesium bromide (925-90-6) → 1-(3-chlorophenyl)propylamine (40023-86-7,1075715-57-9,1168139-52-3)

Guidance literature:

m-Chlorobenzaldehyde; With lithium hexamethyldisilazane; In tetrahydrofuran; at 0 ℃; for 0.333333h;

ethylmagnesium bromide; In tetrahydrofuran; diethyl ether; for 24h; Heating / reflux;

Reference yield:

3'-chloro-propiophenone (34841-35-5) → 1-(3-chlorophenyl)propylamine (40023-86-7,1075715-57-9,1168139-52-3)

Guidance literature:

Multi-step reaction with 2 steps

1: NH₂OH*HCl; NaOAc / methanol / 18 h / 20 °C

2: H₂; thiophene; NH₃ / RaNi / methanol

With thiophene; hydroxylamine hydrochloride; ammonia; hydrogen; sodium acetate; RaNi; In methanol;

DOI:10.1016/j.bmcl.2004.11.064

upstream raw materials:

3'-chloro-propiophenone

ethylmagnesium bromide

m-Chlorobenzaldehyde

3-chloro-benzonitrile

Refernces

• 1、 Van Lommen, Guy,Doyon, Julien,Coesemans, Erwin,Boeckx, Staf,Cools, Marina,Buntinx, Mieke,Hermans, Bart,VanWauwe, Jean. "2-Mercaptoimidazoles, a new class of potent CCR2 antagonists". . p. 497 - 500. Retrieved 2007/10/03.
• 2、 -. "ISOTHIAZOLE DIOXIDES AS CXC- AND CC- CHEMOKINE RECEPTOR LIGANDS". Page/Page column 201. . Retrieved 2010/02/13.