2H-Carbazol-2-one, 1,3,4,9-tetrahydro-

Base Information

• Chemical Name: 2H-Carbazol-2-one, 1,3,4,9-tetrahydro-
• CAS No.: 40429-00-3
• Molecular Formula: C12H11NO
• Molecular Weight: 185.225
• Mol file: 40429-00-3.mol

Synonyms:1,3,4,9-tetrahydrocarbazol-2-one;1,3,4,9-tetrahydro-carbazol-2-one;2-oxo-1,2,3,4-tetrahydrocarbazole;2,3,4,9-tetrahydro-2H-carbazol-2-one;2-Oxo-1,2,3,4-tetrahydro-carbazol;2,3,4,9-tetrahydro-1H-2-carbazolone;

Chemical Property of 2H-Carbazol-2-one, 1,3,4,9-tetrahydro-

Chemical Property:

• PSA: 32.86000
• LogP: 2.22570

Purity/Quality:

99% ^*data from raw suppliers

3,4-Dihydro-1H-carbazol-2(9H)-one 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2H-Carbazol-2-one, 1,3,4,9-tetrahydro-

There total 8 articles about 2H-Carbazol-2-one, 1,3,4,9-tetrahydro- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

1-diazo-4-(3-indolyl)-2-butanoate (313663-92-2) → 1,3,4,9-tetrahydro-2H-carbazol-2-one (40429-00-3)

Guidance literature:

dirhodium tetraacetate; In dichloromethane; for 3h; Heating;

DOI:10.1016/j.tet.2003.12.019

Reference yield: 53.3%

1,3,4,9-tetrahydrospiro[carbazole-2,2'-[1,3]dioxolane] (128266-93-3) → 1,3,4,9-tetrahydro-2H-carbazol-2-one (40429-00-3)

Guidance literature:

1,3,4,9-tetrahydrospiro[carbazole-2,2'-[1,3]dioxolane]; With sulfuric acid; In methanol; water; at 25 - 30 ℃; for 6h; Inert atmosphere;

Inert atmosphere;

DOI:10.1016/j.ejmech.2017.02.062

Reference yield:

Indole-3-propionic acid (830-96-6) → 1,3,4,9-tetrahydro-2H-carbazol-2-one (40429-00-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: N-methylmorpholine; ClCO₂Et / diethyl ether / 0 °C

1.2: 87 percent / diethyl ether / 0 - 20 °C

2.1: 82 percent / Rh₂(OAc)4 / CH₂Cl₂ / 3 h / Heating

With 4-methyl-morpholine; chloroformic acid ethyl ester; dirhodium tetraacetate; In diethyl ether; dichloromethane;

DOI:10.1016/j.tet.2003.12.019

upstream raw materials:

2-methoxy-1,4-dihydro-carbazole

1-diazo-4-(3-indolyl)-2-butanoate

Indole-3-propionic acid

indole-3-propionic acid chloride

Downstream raw materials:

2-benzylaminocarbazole

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