Benzofuran, 2-(2-phenylethenyl)-

Base Information

• Chemical Name: Benzofuran, 2-(2-phenylethenyl)-
• CAS No.: 40723-99-7
• Molecular Formula: C16H12O
• Molecular Weight: 220.271
• DSSTox Substance ID: DTXSID30361237
• Mol file: 40723-99-7.mol

Synonyms:Benzofuran, 2-(2-phenylethenyl)-;DTXSID30361237

Chemical Property of Benzofuran, 2-(2-phenylethenyl)-

Chemical Property:

• XLogP3: 4.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 220.088815002
• Heavy Atom Count: 17
• Complexity: 265

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C=CC2=CC3=CC=CC=C3O2

Technology Process of Benzofuran, 2-(2-phenylethenyl)-

There total 10 articles about Benzofuran, 2-(2-phenylethenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

Triphenyl-{2-[(E)-(3-phenyl-acryloyl)oxy]-benzyl}-phosphonium; bromide → styryl-2 benzofuranne (40723-99-7)

Guidance literature:

With triethylamine; In toluene; for 3h; Heating;

DOI:10.1016/S0040-4020(01)92357-9

Reference yield: 68.0%

2-bromo-1-benzofuran (54008-77-4) → styryl-2 benzofuranne (40723-99-7)

Guidance literature:

With 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; palladium dichloride; In 1,2-dichloro-ethane; at 80 ℃; for 4h; Inert atmosphere; Schlenk technique;

DOI:10.1039/d0ra02984j

Reference yield:

2-methylphenyl acetate (533-18-6) → styryl-2 benzofuranne (40723-99-7)

Guidance literature:

Multi-step reaction with 5 steps

1: 71 percent / bromine / CCl₄ / Heating; Irradiation

2: 94 percent / toluene / 4 h / Heating

3: 97 percent / 48 percent HBr / H₂O / 3 h / Heating

4: pyridine / CHCl₃ / 3 h / Heating

5: 70 percent / triethylamine / toluene / 3 h / Heating

With pyridine; hydrogen bromide; bromine; triethylamine; In tetrachloromethane; chloroform; water; toluene;

DOI:10.1016/S0040-4020(01)92357-9

upstream raw materials:

2-methylphenyl acetate

salicylic alcohol

2-(bromomethyl)phenyl acetate

cinnamoyl chloride

Refernces

• 1、 Hercouet,Le Corre. "-". . p. 2867 - 2873. Retrieved 2007/10/02.