Oxo-thiophen-2-yl-acetyl chloride

Base Information

Chemical Name:Oxo-thiophen-2-yl-acetyl chloride
CAS No.:4075-60-9
Molecular Formula:C6H3ClO2S
Molecular Weight:174.608
Hs Code.:
DSSTox Substance ID:DTXSID701302470
Nikkaji Number:J2.206.306E
Mol file:4075-60-9.mol

Synonyms:4075-60-9;Oxo-thiophen-2-yl-acetyl chloride;SCHEMBL1883541;SZNAAPJHZVKWKD-UHFFFAOYSA-N;DTXSID701302470;alpha-Oxo-2-thiopheneacetyl chloride

Suppliers and Price of Oxo-thiophen-2-yl-acetyl chloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 4 raw suppliers

Chemical Property of Oxo-thiophen-2-yl-acetyl chloride

Chemical Property:

Boiling Point:216 - 218 °C (6 mmHg)
PSA：62.38000
LogP:1.69620
XLogP3:2.1
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:173.9542282
Heavy Atom Count:10
Complexity:169

Purity/Quality:: 95% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CSC(=C1)C(=O)C(=O)Cl

Technology Process of Oxo-thiophen-2-yl-acetyl chloride

There total 5 articles about Oxo-thiophen-2-yl-acetyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 4075-59-6
2-thiopheneglyoxylic acid

: 4075-60-9
oxo-thiophen-2-yl-acetyl chloride

Guidance literature:: With Dichloromethyl methyl ether; at 20 - 50 ℃; Inert atmosphere;
DOI:10.1016/j.tet.2010.06.005

Reference yield:

: methyl 2-hydroxy-2-(thiophen-2-yl)acetate

: 4075-60-9
oxo-thiophen-2-yl-acetyl chloride

Guidance literature:: Multi-step reaction with 3 steps

1: VOCl₃; O₂ / acetonitrile

2: KOH / H₂O; ethanol

3: oxalyl chloride / CH₂Cl₂ / 0.5 h / cooling

With potassium hydroxide; oxalyl dichloride; oxygen; vanadium(V) oxychloride; In ethanol; dichloromethane; water; acetonitrile;
DOI:10.1021/jo070575f

Reference yield:

: 26878-13-7
methyl 2-thienylglyoxylate

: 4075-60-9
oxo-thiophen-2-yl-acetyl chloride

Guidance literature:: Multi-step reaction with 2 steps

1: KOH / H₂O; ethanol

2: oxalyl chloride / CH₂Cl₂ / 0.5 h / cooling

With potassium hydroxide; oxalyl dichloride; In ethanol; dichloromethane; water;
DOI:10.1021/jo070575f