1-OCTYL-PYRROLE-2,5-DIONE

Base Information

• Chemical Name: 1-OCTYL-PYRROLE-2,5-DIONE
• CAS No.: 4080-76-6
• Molecular Formula: C12H19NO2
• Molecular Weight: 209.28500
• Hs Code.: 2925190090
• Mol file: 4080-76-6.mol

Synonyms:1-octylpyrrole-2,5-dione;

Chemical Property of 1-OCTYL-PYRROLE-2,5-DIONE

Chemical Property:

• Melting Point: 35-37oC
• Boiling Point: 142 °C
• PKA: -2.18±0.20(Predicted)
• PSA: 37.38000
• Density: 1.032±0.06 g/cm3(Predicted)
• LogP: 2.20980
• Storage Temp.: -20°C Freezer

Purity/Quality:

98%Min ^*data from raw suppliers

Octyl Maleimide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: A sonic hedgehog inhibitor. Also a possible inhibitor of prostaglandin endoperodixide synthases

Technology Process of 1-OCTYL-PYRROLE-2,5-DIONE

There total 6 articles about 1-OCTYL-PYRROLE-2,5-DIONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

maleic anhydride (108-31-6) + n-Octylamine (111-86-4) → N-octylmaleimide (4080-76-6)

Guidance literature:

maleic anhydride; n-Octylamine; In toluene; at 30 ℃; for 1h;

With 1,1,1,3,3,3-hexamethyl-disilazane; zinc dibromide; In toluene; at 85 ℃; for 2h;

DOI:10.1002/chem.202103808

Reference yield: 68.0%

N-Octyl maleamic acid (3151-55-1) → N-octylmaleimide (4080-76-6)

Guidance literature:

With sodium acetate; acetic anhydride; at 90 ℃; for 2h;

DOI:10.1021/jm950872p

Reference yield: 68.0%

n-Octylamine (111-86-4) + 2-butenedioic acid (6915-18-0,26099-09-2) → N-octylmaleimide (4080-76-6)

Guidance literature:

With niobium(V) oxide; In hexane; for 18h; Inert atmosphere; Reflux; Microwave irradiation;

DOI:10.1002/chem.201404538

upstream raw materials:

maleic anhydride

n-Octylamine

N-Octyl maleamic acid

2-butenedioic acid

Downstream raw materials:

N,N'-bis(octyl)-3,9-dihydroxy-3,9-bis(phenyl)-1,2,3,7,8,9,13,14-octahydro-perylene-1,2,7,8-tetracarbonyl bisimide

C₂₆H₂₉NO₄

C₄₀H₃₇NO₄

C₄₁H₃₆N₂O₄

Refernces

• 1、 Fan, Yongxian,Lu, Yuele,Chen, Xiaolong,Tekwani, Babu,Li, Xing-Cong,Shen, Yinchu. "Anti-leishmanial and cytotoxic activities of a series of maleimides: Synthesis, biological evaluation and structure-activity relationship". . . Retrieved 2018/11/24.
• 2、 Uchoa, Adjaci F.,De Oliveira, Kleber T.,Baptista, Mauricio S.,Bortoluzzi, Adailton J.,Iamamoto, Yassuko,Serra, Osvaldo A.. "Chlorin photosensitizers sterically designed to prevent self-aggregation". experimental part. p. 8824 - 8832. Retrieved 2011/12/21.