3-(4-METHOXYCARBONYLPHENYL)PROPIONIC ACID METHYL ESTER

Base Information

• Chemical Name: 3-(4-METHOXYCARBONYLPHENYL)PROPIONIC ACID METHYL ESTER
• CAS No.: 40912-11-6
• Molecular Formula: C12H14O4
• Molecular Weight: 222.241
• Hs Code.: 2918990090
• Mol file: 40912-11-6.mol

Synonyms:3-(4-Methoxycarbonylphenyl)propionic Acid Methyl Ester;3-(4-Carboxyphenyl)propionic Acid Dimethyl Ester;Methyl 4-(3-methoxy-3-oxopropyl)benzoate;

Chemical Property of 3-(4-METHOXYCARBONYLPHENYL)PROPIONIC ACID METHYL ESTER

Chemical Property:

• Melting Point: 33 °C
• PSA: 52.60000
• LogP: 1.57880
• Storage Temp.: Refrigerator
• Solubility.: Dichloromethane, Ethyl Acetate

Purity/Quality:

97% ^*data from raw suppliers

3-(p-Carboxyphenyl)propionicAcidDimethylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Methyl 3-(4-Methoxycarbonylphenyl)propionate is a benzoic acid derivative used in the preparation of potent, selective, orally bioavailable matrix metalloproteinase inhibitors.

Technology Process of 3-(4-METHOXYCARBONYLPHENYL)PROPIONIC ACID METHYL ESTER

There total 6 articles about 3-(4-METHOXYCARBONYLPHENYL)PROPIONIC ACID METHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

methyl (E)-4-(3-methoxy-3-oxoprop-1-en-1-yl)benzoate (52148-89-7) → 3-(4-(methoxycarbonyl)phenyl)propanoic acid methyl ester (40912-11-6)

Guidance literature:

With palladium on activated charcoal; hydrogen; In ethyl acetate; at 20 ℃;

DOI:10.1002/ejoc.200800494

Reference yield: 64.0%

Methyl 4-chlorobenzoate (1126-46-1) + acrylic acid methyl ester (292638-85-8,9003-21-8,96-33-3) → 3-(4-(methoxycarbonyl)phenyl)propanoic acid methyl ester (40912-11-6)

Guidance literature:

With manganese; water; trifluoroacetic acid; cobalt 2,2'-bipyridine dibromide; lithium bromide; In pyridine; N,N-dimethyl-formamide; at 80 ℃;

DOI:10.1021/jo060855f

Reference yield: 55.0%

4-methoxycarbonylphenyl bromide (619-42-1) + acrylic acid methyl ester (292638-85-8,9003-21-8,96-33-3) → 3-(4-(methoxycarbonyl)phenyl)propanoic acid methyl ester (40912-11-6)

Guidance literature:

With pyridine; nickel(II) dichloro tris(triphenylphoshpine); zinc; In acetonitrile; at 65 ℃; for 4h;

upstream raw materials:

methyl (E)-4-(3-methoxy-3-oxoprop-1-en-1-yl)benzoate

4-methoxycarbonylphenyl bromide

acrylic acid methyl ester

Methyl 4-chlorobenzoate

Downstream raw materials:

3-(4-methoxycarbonylphenyl)propanoic acid

methyl 3-bromo-4-[2-(methoxycarbonyl)ethyl]benzoate

3-<4-(hydroxymethyl)phenyl>propanol

methyl 4-(3-methoxy-3-oxopropyl)-3-nitrobenzoate