ala-ala-ala methyl ester acetate

Base Information

• Chemical Name: ala-ala-ala methyl ester acetate
• CAS No.: 41036-27-5
• Molecular Formula: C10H19N3O4.ClH
• Molecular Weight: 281.739
• Mol file: 41036-27-5.mol

Synonyms:

Chemical Property of ala-ala-ala methyl ester acetate

Chemical Property:

• Vapor Pressure: 5.74E-09mmHg at 25°C

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ala-ala-ala methyl ester acetate

There total 5 articles about ala-ala-ala methyl ester acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

Nα-tert-butoxycarbonyl-L-alanyl-L-alanyl-L-alanine methyl ester (19963-33-8) → H-Ala3-OMe*HCl (41036-27-5)

Guidance literature:

With hydrogenchloride; In ethyl acetate; at 0 ℃; for 2h;

DOI:10.1246/bcsj.67.2478

Reference yield: 100.0%

N-[(benzyloxy)carbonyl]-L-alanyl-L-alanyl-L-alanine methyl ester (3057-69-0) → H-Ala3-OMe*HCl (41036-27-5)

Guidance literature:

With hydrogenchloride; hydrogen; palladium; In methanol;

Reference yield:

L-alanyl-alanine methylester hydrochloride (41036-19-5,105328-90-3) → H-Ala3-OMe*HCl (41036-27-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 89 percent / Et₃N, DCC / CH₂Cl₂ / 0 - 20 °C

2: 100 percent / HCl / ethyl acetate / 2 h / 0 °C

With hydrogenchloride; triethylamine; dicyclohexyl-carbodiimide; In dichloromethane; ethyl acetate;

DOI:10.1246/bcsj.67.2478

upstream raw materials:

N-[(benzyloxy)carbonyl]-L-alanyl-L-alanyl-L-alanine methyl ester

N^α-tert-butoxycarbonyl-L-alanyl-L-alanyl-L-alanine methyl ester

(S)-methyl 2-((S)-2-((tert-butoxycarbonyl)amino)propanamido)propanoate

L-alanyl-alanine methylester hydrochloride

Downstream raw materials:

H-Ala₅-OMe, HBr

H-Ala₅-OMe, HCl

N-acetyltri-L-alanyl methyl ester

Z-Ala₅-OMe

Refernces

• 1、 Jahreis, Guenther,Fittkau, Siegfried. "Thermitase - A Thermostable Serine Protease. I. Synthesis of Alanine Peptide Esters as Substrates of the Enzyme". . p. 35 - 40. Retrieved 2007/10/02.