1-[(2R)-1,2,3,4-Tetrahydro-2-hydroxy-5,8-dimethoxy-2-naphthalenyl]-ethanone

Base Information

Chemical Name:1-[(2R)-1,2,3,4-Tetrahydro-2-hydroxy-5,8-dimethoxy-2-naphthalenyl]-ethanone
CAS No.:41098-96-8
Molecular Formula:C14H18O4
Molecular Weight:250.295
Hs Code.:
Mol file:41098-96-8.mol

Synonyms:(-)-2(R)-acetyl-5,8-dimethoxy-1,2,3,4-tetrahydro-2(R)-naphthol;1-[(2R)-1,2,3,4-tetrahydro-2-hydroxy-5,8-dimethoxy-2-naphthalenyl]-Ethanone Aglycone Anticancer API interMediate;(R)-(-)-2-acetyl-5,8-dimethoxy-1,2,3,4-tetrahydro-2-naphtol;(-)-PGE1 methyl ester;(R)-(-)-2-acetyl-1,2,3,4-tetrahydro-5,8-dimethoxy-2-naphthol;(R)-(-)-2-acetyl-5,8-dimethoxy-1,2,3,4-tetrahydro-2-naphthol;

Suppliers and Price of 1-[(2R)-1,2,3,4-Tetrahydro-2-hydroxy-5,8-dimethoxy-2-naphthalenyl]-ethanone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Chemenu
(R)-1-(2-hydroxy-5,8-dimethoxy-1,2,3,4-tetrahydronaphthalen-2-yl)ethan-1-one 97%
1g
$ 1664.00

Total 6 raw suppliers

Chemical Property of 1-[(2R)-1,2,3,4-Tetrahydro-2-hydroxy-5,8-dimethoxy-2-naphthalenyl]-ethanone

Chemical Property:

Melting Point:128-129℃ (ethyl ether hexane )
PSA：55.76000
Density:1.186±0.06 g/cm3 (20 oC 760 Torr)
LogP:1.51260

Purity/Quality:

98%Min ^*data from raw suppliers

(R)-1-(2-hydroxy-5,8-dimethoxy-1,2,3,4-tetrahydronaphthalen-2-yl)ethan-1-one 97% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

General Description 1-[(2R)-1,2,3,4-Tetrahydro-2-hydroxy-5,8-dimethoxy-2-naphthalenyl]-ethanone, also known as (R)-(-)-2-acetyl-5,8-dimethoxy-1,2,3,4-tetrahydro-2-naphthol, is a key chiral intermediate in the synthesis of anthracycline antibiotics and anthracyclinones. It can be prepared enantioselectively via hydroxylation of a potassium enolate using an N-sulfonyloxaziridine or through Sharpless asymmetric dihydroxylation followed by regioselective transformations, yielding the compound with high enantiomeric excess (>95% ee) and satisfactory overall yields (35–52%). Its synthesis is notable for efficiency and minimal purification requirements.

Technology Process of 1-[(2R)-1,2,3,4-Tetrahydro-2-hydroxy-5,8-dimethoxy-2-naphthalenyl]-ethanone

There total 62 articles about 1-[(2R)-1,2,3,4-Tetrahydro-2-hydroxy-5,8-dimethoxy-2-naphthalenyl]-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%