1H-Indole-3-carboxaldehyde, 2-(4-chlorophenyl)-1-methyl-

Base Information

Chemical Name:1H-Indole-3-carboxaldehyde, 2-(4-chlorophenyl)-1-methyl-
CAS No.:41113-01-3
Molecular Formula:C16H12ClNO
Molecular Weight:269.73
Hs Code.:
Mol file:41113-01-3.mol

Synonyms:

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Chemical Property of 1H-Indole-3-carboxaldehyde, 2-(4-chlorophenyl)-1-methyl-

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Technology Process of 1H-Indole-3-carboxaldehyde, 2-(4-chlorophenyl)-1-methyl-

There total 9 articles about 1H-Indole-3-carboxaldehyde, 2-(4-chlorophenyl)-1-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 5905-11-3
2-(4-chlorophenyl)-1-methyl-2-phenyl-1H-indole

: 41113-01-3
2-(4-chloro-phenyl)-1-methyl-indole-3-carbaldehyde

Guidance literature:: With palladium(II) trifluoroacetate; oxygen; copper diacetate; trifluoroacetic acid; In N,N-dimethyl-formamide; at 120 ℃; Schlenk technique;

Reference yield:

: C₂₃H₂₁ClN₄O₂S

: 41113-01-3
2-(4-chloro-phenyl)-1-methyl-indole-3-carbaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1: rhodium(II) acetate dimer / toluene / 2 h / 85 °C / Inert atmosphere

2: methanol; potassium carbonate / 20 °C

With methanol; rhodium(II) acetate dimer; potassium carbonate; In toluene;
DOI:10.1039/c5ob00085h

Reference yield:

: C₁₄H₁₃ClIN

: 41113-01-3
2-(4-chloro-phenyl)-1-methyl-indole-3-carbaldehyde

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine; tetrakis(triphenylphosphine)palladium dichloride; copper(l) iodide / 20 °C / Inert atmosphere

2: potassium fluoride / methanol / 20 °C

3: copper(I) thiophene-2-carboxylate / toluene / 20 °C

4: rhodium(II) acetate dimer / toluene / 2 h / 85 °C / Inert atmosphere

5: methanol; potassium carbonate / 20 °C

With methanol; potassium fluoride; copper(l) iodide; copper(I) thiophene-2-carboxylate; rhodium(II) acetate dimer; tetrakis(triphenylphosphine)palladium dichloride; potassium carbonate; triethylamine; In methanol; toluene; 1: |Sonogashira Cross-Coupling;
DOI:10.1039/c5ob00085h