N-BOC-L-VALINE-O-NITROPHENYL ESTER

Base Information

• Chemical Name: N-BOC-L-VALINE-O-NITROPHENYL ESTER
• CAS No.: 41120-72-3
• Molecular Formula: C16H22N2O6
• Molecular Weight: 338.35600
• Hs Code.: 2924299090
• Mol file: 41120-72-3.mol

Synonyms:N-Boc-L-valine-O-nitrophenyl Ester;

Chemical Property of N-BOC-L-VALINE-O-NITROPHENYL ESTER

Chemical Property:

• PSA: 110.45000
• LogP: 3.96360
• Solubility.: Chloroform, Ethyl Acetate, Methanol, Tetrahydrofuran

Purity/Quality:

97% ^*data from raw suppliers

N-Boc-L-valine-O-nitrophenyl ester ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-BOC-L-VALINE-O-NITROPHENYL ESTER

There total 2 articles about N-BOC-L-VALINE-O-NITROPHENYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

t-Boc-L-valine (13734-41-3) + 2-hydroxynitrobenzene (88-75-5,78813-12-4) → N-Boc-L-valine o-nitrophenyl ester (41120-72-3)

Guidance literature:

With pyridine; dicyclohexyl-carbodiimide; for 1h;

DOI:10.1039/P19930000459

Reference yield:

→ Boc-DL-Val-ONO (41120-72-3)

Guidance literature:

Boc-DL-Val, o-Nitrophenol;

DOI:10.1021/ja00814a039

Reference yield:

N-Boc-L-valine o-nitrophenyl ester (41120-72-3) → 2-benzyloxymethyl-N-(N-tert-butoxycarbonyl-L-valinyl)pyrrolidine (122501-59-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 85 percent / Et₃N / tetrahydrofuran / 1 h

2: 92 percent / NaH / tetrahydrofuran / 36 h / Ambient temperature

With sodium hydride; triethylamine; In tetrahydrofuran;

DOI:10.1039/P19930000459

upstream raw materials:

t-Boc-L-valine

2-hydroxynitrobenzene

Downstream raw materials:

Boc-Val-NH₂

actinonin

2-benzyloxymethyl-N-(N-tert-butoxycarbonyl-L-valinyl)pyrrolidine

O-Benzyl-N-(L-valyl)-L-prolinol

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