3-(1,3-Benzodioxol-5-yl)-4-hydroxy-5-methoxy-8,8-dimethyl-2H,8H-benzo[1,2-b:5,4-b']dipyran-2-one

Base Information

Chemical Name:3-(1,3-Benzodioxol-5-yl)-4-hydroxy-5-methoxy-8,8-dimethyl-2H,8H-benzo[1,2-b:5,4-b']dipyran-2-one
CAS No.:22044-61-7
Molecular Formula:C₂₂H₁₈O₇
Molecular Weight:394.381
Hs Code.:
Mol file:22044-61-7.mol

Synonyms:2H,8H-Benzo[1,2-b:5,4-b']dipyran-2-one,4-hydroxy-5-methoxy-8,8-dimethyl-3-[3,4-(methylenedioxy)phenyl]- (8CI);Robustin; Robustin (isoflavonoid)

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Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-(1,3-Benzodioxol-5-yl)-4-hydroxy-5-methoxy-8,8-dimethyl-2H,8H-benzo[1,2-b:5,4-b']dipyran-2-one

Chemical Property:

PSA：87.36000
LogP:4.08710

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 3-(1,3-Benzodioxol-5-yl)-4-hydroxy-5-methoxy-8,8-dimethyl-2H,8H-benzo[1,2-b:5,4-b']dipyran-2-one

There total 16 articles about 3-(1,3-Benzodioxol-5-yl)-4-hydroxy-5-methoxy-8,8-dimethyl-2H,8H-benzo[1,2-b:5,4-b']dipyran-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 124010-46-4
<3,4-(Methylenedioxy)phenyl>lead triacetate

: 171021-68-4
4-hydroxy-5-methoxy-8,8-dimethyl-2H,8H-benzo<1,2-b:5,4-b'>-dipyran-2-one

: 22044-61-7
robustin

Guidance literature:: With pyridine; In chloroform; at 60 ℃; for 14h;

Reference yield:

: 541-47-9
3-Methylbutenoic acid

: 22044-61-7
robustin

Guidance literature:: Multi-step reaction with 8 steps

1: 1.) polyphosphoric acid, 2.) potassium carbonate / 1.) dioxane, 60 deg C, 3 h, 2.) acetone, reflux, 50 h

2: 64 percent / potassium carbonate / acetone / 2 h / Heating

3: 93 percent / potassium carbonate / acetone / 4 h / Heating

4: 70 percent / NaBH₄, PdCl₂ / tetrahydrofuran; H₂O / 1.5 h / 0 - 5 °C

5: 92 percent / toluene-p-sulfonic acid / toluene / 0.33 h / Heating

6: 95 percent / potassium carbonate / methanol / 1.5 h / Heating

7: 80 percent / sodium hydride / 0.5 h / 45 °C

8: 84 percent / pyridine / CHCl₃ / 14 h / 60 °C

With pyridine; sodium tetrahydroborate; PPA; sodium hydride; potassium carbonate; toluene-4-sulfonic acid; palladium dichloride; In tetrahydrofuran; methanol; chloroform; water; acetone; toluene;

Reference yield:

: 480-66-0,67471-34-5
2,4,6-trihydroxyacetophenone

: 22044-61-7
robustin

Guidance literature:: Multi-step reaction with 8 steps

1: 1.) polyphosphoric acid, 2.) potassium carbonate / 1.) dioxane, 60 deg C, 3 h, 2.) acetone, reflux, 50 h

2: 64 percent / potassium carbonate / acetone / 2 h / Heating

3: 93 percent / potassium carbonate / acetone / 4 h / Heating

4: 70 percent / NaBH₄, PdCl₂ / tetrahydrofuran; H₂O / 1.5 h / 0 - 5 °C

5: 92 percent / toluene-p-sulfonic acid / toluene / 0.33 h / Heating

6: 95 percent / potassium carbonate / methanol / 1.5 h / Heating

7: 80 percent / sodium hydride / 0.5 h / 45 °C

8: 84 percent / pyridine / CHCl₃ / 14 h / 60 °C

With pyridine; sodium tetrahydroborate; PPA; sodium hydride; potassium carbonate; toluene-4-sulfonic acid; palladium dichloride; In tetrahydrofuran; methanol; chloroform; water; acetone; toluene;