1H-INDOLE-3-ETHANOL,7-CHLORO-

Base Information

• Chemical Name: 1H-INDOLE-3-ETHANOL,7-CHLORO-
• CAS No.: 41340-34-5
• Molecular Formula: C10H10ClNO
• Molecular Weight: 195.64500
• Hs Code.: 2933990090
• Mol file: 41340-34-5.mol

Synonyms:7-chlorotryptophol;7-Chlortryptophol;2-(7-chloro-indol-3-yl)-ethanol;

Chemical Property of 1H-INDOLE-3-ETHANOL,7-CHLORO-

Chemical Property:

• PSA: 36.02000
• LogP: 2.35610
• Storage Temp.: 2-8°C

Purity/Quality:

95+% ^*data from raw suppliers

1H-INDOLE-3-ETHANOL,7-CHLORO- 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1H-INDOLE-3-ETHANOL,7-CHLORO-

There total 6 articles about 1H-INDOLE-3-ETHANOL,7-CHLORO- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-(3-indole)-ethanol (526-55-6,930395-07-6) → 2-(7-chloro-1H-indol-3-yl)ethanol (41340-34-5)

Guidance literature:

With glucose dehydrogenase; D-gulose; maltose binding protein-fused recombinant flavin reductase; recombinant tryptophan-7-halogenase; NAD; flavin adenine dinucleotide; sodium chloride; In isopropyl alcohol; at 25 ℃; pH=7.4; regioselective reaction; Enzymatic reaction;

DOI:10.1002/anie.201300762

Reference yield: 75.0%

(7-Chloro-1H-indol-3-yl)-oxo-acetic acid ethyl ester (863289-30-9) → 2-(7-chloro-1H-indol-3-yl)ethanol (41340-34-5)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 18h; Heating;

DOI:10.1016/j.bmcl.2005.07.077

Reference yield:

2,3-dihydro-2H-furan (1191-99-7,75454-45-4) + o-chlorophenylhydrazine hydrochloride (41052-75-9) → 2-(7-chloro-1H-indol-3-yl)ethanol (41340-34-5)

Guidance literature:

With sulfuric acid; In N,N-dimethyl acetamide; water; at 100 ℃; for 2h;

DOI:10.1021/acs.orglett.1c00411

upstream raw materials:

(7-Chloro-1H-indol-3-yl)-oxo-acetic acid ethyl ester

7-chloro-1H-indole

2-(7-chloro-1H-indol-3-yl)-2-oxoacetyl chloride

2-(3-indole)-ethanol

Downstream raw materials:

7-chloro-3-(2-iodo-ethyl)-1H-indole

3-(2-bromo-ethyl)-7-chloro-1H-indole

Refernces

• 1、 Payne, James T.,Andorfer, Mary C.,Lewis, Jared C.. "Regioselective arene halogenation using the FAD-dependent halogenase RebH". supporting information. p. 5271 - 5274. Retrieved 2013/06/26.
• 2、 Teng, Xin,Degterev, Alexei,Jagtap, Prakash,Xing, Xuechao,Choi, Sungwoon,Denu, Regine,Yuan, Junying,Cuny, Gregory D.. "Structure-activity relationship study of novel necroptosis inhibitors". . p. 5039 - 5044. Retrieved 2007/10/03.