Technology Process of 4'-Demethylamino-4'-hydroxystaurosporine
There total 14 articles about 4'-Demethylamino-4'-hydroxystaurosporine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
methoxybenzene; trifluoroacetic acid;
DOI:10.1021/ja9626143
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 89 percent / LiBH4 / tetrahydrofuran / 0.33 h
2: 71 percent / pyridinium trifluoroacetate, 1,3-dicyclohexylcarbodiimide / benzene; dimethylsulfoxide / 9 h / Ambient temperature
3: 85 percent / BF3*OEt2 / diethyl ether / 24 h / 25 - 30 °C
4: 95 percent / NaBH4 / methanol; CH2Cl2; CHCl3 / 0.08 h
5: 1.) NaH / 1) THF, 25 min; 2) THF, 50 min
6: 75 percent / TFA, thioanisole / 24 h
With
sodium tetrahydroborate; lithium borohydride; methyl-phenyl-thioether; boron trifluoride diethyl etherate; pyridinium trifluroacetate; sodium hydride; dicyclohexyl-carbodiimide; trifluoroacetic acid;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane; chloroform; dimethyl sulfoxide; benzene;
DOI:10.1021/ja971304x
