Benzyl 3,4-dihydro-2-(4-fluoro-2-methylphenyl)-4-oxopyridine-1(2H)-carboxylate, 1-[(Benzyloxy)carbonyl]-2-(4-fluoro-2-methylphenyl)-4-oxo-1,2,3,4-tetrahydropyridine

Base Information

Chemical Name:Benzyl 3,4-dihydro-2-(4-fluoro-2-methylphenyl)-4-oxopyridine-1(2H)-carboxylate, 1-[(Benzyloxy)carbonyl]-2-(4-fluoro-2-methylphenyl)-4-oxo-1,2,3,4-tetrahydropyridine
CAS No.:414909-98-1
Molecular Formula:C20H18FNO3
Molecular Weight:339.366
Hs Code.:2933399990
Mol file:414909-98-1.mol

Benzyl 3,4-dihydro-2-(4-fluoro-2-methylphenyl)-4-oxopyridine-1(2H)-carboxylate, 1-[(Benzyloxy)carbonyl]-2-(4-fluoro-2-methylphenyl)-4-oxo-1,2,3,4-tetrahydropyridine

Synonyms:1-[(Benzyloxy)carbonyl]-2-(4-fluoro-2-methylphenyl)-4-oxo-1,2,3,4-tetrahydropyridine;phenylmethyl 2-(4-fluoro-2-methylphenyl)-4-oxo-3,4-dihydro-1(2H)-pyridinecarboxylate;1-(benzyloxycarbonyl)-2-(4-fluoro-2-methyl-phenyl)-2,3-dihydro-4-pyridone;BENZYL 2-(4-FLUORO-2-METHYLPHENYL)-4-OXO-3,4-DIHYDRO-1(2H)-PYRIDINE-CARBOXYLATE;1-Benzyloxycarbonyl-2-(4-fluoro-2-methylphenyl)-4-oxo-2,3-dihydro-1H-pyridine;1-benzyloxycarbonyl-2-(4-fluoro-2-methylphenyl)-4-oxo-3,4-dihydro-2H-pyridine;2-(4-fluoro-2-methyl-phenyl)-4-oxo-3,4-dihydro-2H-pyridine-1-carboxylic acid benzyl ester;

Suppliers and Price of Benzyl 3,4-dihydro-2-(4-fluoro-2-methylphenyl)-4-oxopyridine-1(2H)-carboxylate, 1-[(Benzyloxy)carbonyl]-2-(4-fluoro-2-methylphenyl)-4-oxo-1,2,3,4-tetrahydropyridine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Benzyl 3,4-dihydro-2-(4-fluoro-2-methylphenyl)-4-oxopyridine-1(2H)-carboxylate, 1-[(Benzyloxy)carbonyl]-2-(4-fluoro-2-methylphenyl)-4-oxo-1,2,3,4-tetrahydropyridine

Chemical Property:

Vapor Pressure:0mmHg at 25°C
Boiling Point:493.0±45.0 °C(Predicted)
PKA:-5.12±0.40(Predicted)
PSA：46.61000
Density:1?+-.0.06 g/cm3(Predicted)
LogP:4.23840

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Benzyl 3,4-dihydro-2-(4-fluoro-2-methylphenyl)-4-oxopyridine-1(2H)-carboxylate, 1-[(Benzyloxy)carbonyl]-2-(4-fluoro-2-methylphenyl)-4-oxo-1,2,3,4-tetrahydropyridine

There total 5 articles about Benzyl 3,4-dihydro-2-(4-fluoro-2-methylphenyl)-4-oxopyridine-1(2H)-carboxylate, 1-[(Benzyloxy)carbonyl]-2-(4-fluoro-2-methylphenyl)-4-oxo-1,2,3,4-tetrahydropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 620-08-6,1232006-56-2
4-methoxypyridine

: 452-63-1
2-Bromo-5-fluorotoluene

: 501-53-1,94274-21-2
benzyl chloroformate

: 414909-98-1
phenylmethyl 2-(4-fluoro-2-methylphenyl)-4-oxo-3,4-dihydro-1(2H)-pyridinecarboxylate

Guidance literature:: 2-Bromo-5-fluorotoluene; With iodine; magnesium; In tetrahydrofuran; at 35 - 70 ℃; Inert atmosphere; Reflux; Large scale reaction;

4-methoxypyridine; benzyl chloroformate; In tetrahydrofuran; at -20 - 30 ℃; Inert atmosphere; Large scale reaction;
DOI:10.1021/jm1013264

Reference yield:

: 452-63-1
2-Bromo-5-fluorotoluene

: 1-Benzyloxycarbonyl-4-methoxy-pyridinium; chloride

: 414909-98-1
phenylmethyl 2-(4-fluoro-2-methylphenyl)-4-oxo-3,4-dihydro-1(2H)-pyridinecarboxylate

Guidance literature:: 2-Bromo-5-fluorotoluene; With magnesium; iodine; In tetrahydrofuran; at 20 ℃; for 2.33333h; Heating / reflux;

1-Benzyloxycarbonyl-4-methoxy-pyridinium; chloride; In tetrahydrofuran; at -20 - 20 ℃; for 1h;

With hydrogenchloride; In tetrahydrofuran; water;