Daglutril

Base Information

• Chemical Name: Daglutril
• CAS No.: 182821-27-8
• Molecular Formula: C31H38N2O6
• Molecular Weight: 534.6432
• UNII: KKV299446X
• DSSTox Substance ID: DTXSID60171341
• Wikidata: Q27076974
• NCI Thesaurus Code: C73039
• Metabolomics Workbench ID: 149565
• ChEMBL ID: CHEMBL4799605
• Mol file: 182821-27-8.mol

Synonyms:daglutril;SLV 306;SLV-306;SLV306

Chemical Property of Daglutril

Chemical Property:

• Vapor Pressure: 3.6E-27mmHg at 25°C
• Boiling Point: 802.3°C at 760 mmHg
• Flash Point: 439°C
• PSA: 116.50000
• Density: 1.25g/cm³
• LogP: 5.20310
• XLogP3: 4.9
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 12
• Exact Mass: 534.27298694
• Heavy Atom Count: 39
• Complexity: 863

Purity/Quality:

99% ^*data from raw suppliers

Daglutril-SLV306 99% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CCOC(=O)C(CCC1=CC=CC=C1)CC2(CCCC2)C(=O)NC3CCC4=CC=CC=C4N(C3=O)CC(=O)O
• Isomeric SMILES: CCOC(=O)[C@H](CCC1=CC=CC=C1)CC2(CCCC2)C(=O)N[C@H]3CCC4=CC=CC=C4N(C3=O)CC(=O)O
• Recent ClinicalTrials: Study to Evaluate the Efficacy and Safety of SLV306 in Subjects With Hypertension
• Recent EU Clinical Trials: A randomized, placebo-controlled, double-blind, six-arm, dose escalation, multi-center study to evaluate the efficacy and safety of SLV306: 150, 300, 600 mg once daily, 150-300 mg twice daily and amlodipine 5-10 mg once daily in subjects with hypertension

Technology Process of Daglutril

There total 2 articles about Daglutril which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-{1-[2'-(ethoxycarbonyl)-4'-phenylbutyl]-cyclopentane-1-carbonylamino}-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepine-1-acetic acid tert butylester → 2-[1-(1-carboxymethyl-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-ylcarbamoyl)-cyclopentylmethyl]-4-phenyl-butyric acid ethyl ester (182821-27-8)

Guidance literature:

In hexane; dichloromethane; trifluoroacetic acid;

Reference yield:

→ Daglutril (182821-27-8)

Guidance literature:

Refernces