2-Amino-1-(4-chlorophenyl)-1-ethanol

Base Information

• Chemical Name: 2-Amino-1-(4-chlorophenyl)-1-ethanol
• CAS No.: 41870-82-0
• Molecular Formula: C8H10ClNO
• Molecular Weight: 171.626
• Hs Code.: 2922199090
• European Community (EC) Number: 838-203-9
• DSSTox Substance ID: DTXSID80903141
• Nikkaji Number: J532.119K
• Mol file: 41870-82-0.mol

Synonyms:2-Amino-1-(4-chlorophenyl)-1-ethanol;41870-82-0;2-amino-1-(4-chlorophenyl)ethanol;2-amino-1-(4-chlorophenyl)ethan-1-ol;MFCD06797373;p-Chlorphenylathanolamin;NoName_3738;2-?Amino-?1-?(4-?chlorophenyl)?-?1-?ethanol;SCHEMBL296405;DTXSID80903141;1-(4-Chlorophenyl)-2-aminoethanol;AKOS000123538;AKOS016051263;2-hydroxy-2-(4-chlorophenyl) ethanamine;alpha-(aminomethyl)-p-chlorobenzyl alcohol;[rac]-2-amino-1-(4-chloro-phenyl)-ethanol;BB 0254094;FT-0679981;EN300-30432;[rac]-2-amino-1-(4-chloro -phenyl)-ethanol;C78214;10Y-0719;J-507724;Z295878600

Chemical Property of 2-Amino-1-(4-chlorophenyl)-1-ethanol

Chemical Property:

• Melting Point: 93-96
• PSA: 46.25000
• LogP: 2.03240
• XLogP3: 0.8
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 171.0450916
• Heavy Atom Count: 11
• Complexity: 113

Purity/Quality:

97% ^*data from raw suppliers

alpha-(Aminomethyl)-4-chlorobenzyl alcohol 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC(=CC=C1C(CN)O)Cl

Technology Process of 2-Amino-1-(4-chlorophenyl)-1-ethanol

There total 14 articles about 2-Amino-1-(4-chlorophenyl)-1-ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

C10H8ClNO3 (127118-87-0) → 2-amino-1-(4-chlorophenyl)ethanol (41870-82-0)

Guidance literature:

C₁₀H₈ClNO₃; With hydrogenchloride; In water; for 1h; Heating / reflux;

With potassium carbonate; In methanol; at 20 ℃; for 0.0833333h;

With sodium tetrahydroborate; In methanol; at 0 - 20 ℃; for 2.5h;

Reference yield: 98.0%

rac-2-azido-1-(4-chlorophenyl)ethanol (861929-21-7) → 2-amino-1-(4-chlorophenyl)ethanol (41870-82-0)

Guidance literature:

With hydrogen; magnesium sulfate; sodium hydroxide; In aq. phosphate buffer; water; isopropyl alcohol; at 30 ℃; for 4h; under 7500.75 Torr; pH=7; Green chemistry;

DOI:10.1039/c3gc41666f

Reference yield: 84.0%

1-(4-chlorophenyl)-2-nitroethanol (89979-04-4) → 2-amino-1-(4-chlorophenyl)ethanol (41870-82-0)

Guidance literature:

With formic acid; hydrogen; In methanol; water;

DOI:10.1016/j.bmc.2017.05.055

upstream raw materials:

4-chlorobenzoyl cyanide

cyano(4-chlorophenyl)methyl acetate

4-chloromandelonitrile

4-chlorobenzaldehyde

Downstream raw materials:

5-(4-chloro-phenyl)-4,5-dihydro-oxazol-2-ylamine

2-anilino-5-(p-chlorophenyl)-2-oxazoline

2-(4-chlorophenyl)-2-chloroethylamine hydrochloride

(E)-2-(4-chlorophenyl)ethenyl isothiocyanate