Oxaprozin Impurity 2

Base Information

• Chemical Name: Oxaprozin Impurity 2
• CAS No.: 24248-49-5
• Molecular Formula: C₁₈H₁₆N₂O₂
• Molecular Weight: 292.337
• Mol file: 24248-49-5.mol

Synonyms:2-Oxazolepropionamide,4,5-diphenyl- (8CI); Wy 22075; b-(4,5-Diphenyloxazol-2-yl)propionamide

Chemical Property of Oxaprozin Impurity 2

Chemical Property:

• Vapor Pressure: 3.94E-10mmHg at 25°C
• Boiling Point: 500°C at 760 mmHg
• Flash Point: 256.2°C
• PSA: 70.11000
• Density: 1.187g/cm³
• LogP: 4.57620

Purity/Quality:

99%min ^*data from raw suppliers

4,5-Diphenyl-2-oxazolepropanamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4,5-Diphenyl-2-oxazolepropanamide is an impurity of Oxaprozin (O845400), an anti-inflammatory drug. Oxaprozin was comparable to Aspirin (A687780).

Technology Process of Oxaprozin Impurity 2

There total 3 articles about Oxaprozin Impurity 2 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

C18H17NO4 → 3-(4,5-diphenyloxazol-2-yl)propanamide (24248-49-5)

Guidance literature:

With ammonium acetate; acetic acid; for 3h; Reflux;

DOI:10.1021/acs.jmedchem.9b00445

Reference yield:

desyl bromide (1484-50-0) → 3-(4,5-diphenyloxazol-2-yl)propanamide (24248-49-5)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / acetonitrile / 6 h / 45 °C

2: acetic acid; ammonium acetate / 3 h / Reflux

With ammonium acetate; acetic acid; triethylamine; In acetonitrile;

DOI:10.1021/acs.jmedchem.9b00445

Reference yield:

→ 3-(4,5-diphenyloxazol-2-yl)propanamide (24248-49-5)

Guidance literature:

entspr. Saeurechlorid, NH3;

upstream raw materials:

desyl bromide

Refernces