2-Bromo-4-fluoro-5-methoxyaniline

Base Information

• Chemical Name: 2-Bromo-4-fluoro-5-methoxyaniline
• CAS No.: 420786-92-1
• Molecular Formula: C7H7BrFNO
• Molecular Weight: 220.041
• Hs Code.: 2921410090
• Mol file: 420786-92-1.mol

Synonyms:2-bromanyl-4-fluoranyl-5-methoxy-aniline;2-bromo-4-fluoro-5-(methyloxy)aniline;2-bromo-4-fluoro-(methyloxy)aniline;QC-685;

Chemical Property of 2-Bromo-4-fluoro-5-methoxyaniline

Chemical Property:

• Boiling Point: 290.6±35.0℃ (760 Torr)
• Flash Point: 129.6±25.9℃
• PSA: 35.25000
• Density: 1.616±0.06 g/cm3 (20 oC 760 Torr)
• LogP: 2.76020
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

97% ^*data from raw suppliers

2-Bromo-4-fluoro-5-methoxyaniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Bromo-4-fluoro-5-methoxyaniline

There total 2 articles about 2-Bromo-4-fluoro-5-methoxyaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

4-bromo-2-fluoro-5-nitrophenyl methyl ether (661463-13-4) → 2-bromo-4-fluoro-5-methoxyaniline (420786-92-1)

Guidance literature:

4-bromo-2-fluoro-5-nitrophenyl methyl ether; With acetic acid; iron; In ethanol; at 100 ℃; for 4h;

With potassium carbonate; In ethanol;

Reference yield:

4-fluoro-3-methoxyaniline (64465-53-8) → 2-bromo-4-fluoro-5-methoxyaniline (420786-92-1)

Guidance literature:

With tetra-N-butylammonium tribromide; In ethyl acetate; at 0 - 20 ℃;

DOI:10.1021/acs.jmedchem.6b01645

Reference yield: 97.0%

2-bromo-4-fluoro-5-methoxyaniline (420786-92-1) + trifluoroacetic anhydride (407-25-0) → N-(2-bromo-4-fluoro-5-methoxyphenyl)-2,2,2-trifluoroacetamide

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 1h;

upstream raw materials:

4-bromo-2-fluoro-5-nitrophenyl methyl ether

4-fluoro-3-methoxyaniline

Downstream raw materials:

6-fluoro-2-methyl-quinolin-5-ol

5-({[2-bromo-4-fluoro-5-(methyloxy)phenyl]amino}methylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione

2-bromo-4-fluoro-5-methoxy-N-(9H-xanthen-9-ylidene)aniline

2-amino-5-fluoro-4-methoxybenzoic acid