3-Hexenoic acid, 5-[[(1,1-dimethylethoxy)carbonyl]amino]-3,4-dimethyl-2-(1-methylethyl)-6 -phenyl-, 1,1-dimethylethyl ester, (2R,3E,5R)-

Base Information

Chemical Name:3-Hexenoic acid, 5-[[(1,1-dimethylethoxy)carbonyl]amino]-3,4-dimethyl-2-(1-methylethyl)-6 -phenyl-, 1,1-dimethylethyl ester, (2R,3E,5R)-
CAS No.:420803-67-4
Molecular Formula:C26H41NO4
Molecular Weight:431.616
Hs Code.:
Mol file:420803-67-4.mol

Synonyms:

Suppliers and Price of 3-Hexenoic acid, 5-[[(1,1-dimethylethoxy)carbonyl]amino]-3,4-dimethyl-2-(1-methylethyl)-6 -phenyl-, 1,1-dimethylethyl ester, (2R,3E,5R)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3-Hexenoic acid, 5-[[(1,1-dimethylethoxy)carbonyl]amino]-3,4-dimethyl-2-(1-methylethyl)-6 -phenyl-, 1,1-dimethylethyl ester, (2R,3E,5R)-

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3-Hexenoic acid, 5-[[(1,1-dimethylethoxy)carbonyl]amino]-3,4-dimethyl-2-(1-methylethyl)-6 -phenyl-, 1,1-dimethylethyl ester, (2R,3E,5R)-

There total 11 articles about 3-Hexenoic acid, 5-[[(1,1-dimethylethoxy)carbonyl]amino]-3,4-dimethyl-2-(1-methylethyl)-6 -phenyl-, 1,1-dimethylethyl ester, (2R,3E,5R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1068-55-9
isopropylmagnesium chloride

: 420803-60-7
tert-butyl (2E)-3[(4R,5R)-4-benzyl-N-(tert-butoxycarbonyl)-5-methyloxazolidin-2-on-5-yl]-3-methylprop-2-enoate

: tert-butyl (2S,5R,3Z)-5-[N-(tert-butyloxycarbonyl)amino]-2-isopropyl-3,4-dimethyl-6-phenylhex-3-enoate

: 420803-67-4
tert-butyl (2R,5R,3E)-5-[N-(tert-butyloxycarbonyl)amino]-2-isopropyl-3,4-dimethyl-6-phenylhex-3-enoate

Guidance literature:: isopropylmagnesium chloride; With lithium chloride; In tetrahydrofuran; at 0 ℃; for 0.166667h;

With boron trifluoride diethyl etherate; In tetrahydrofuran; at -78 ℃; for 0.0833333h;

tert-butyl (2E)-3[(4R,5R)-4-benzyl-N-(tert-butoxycarbonyl)-5-methyloxazolidin-2-on-5-yl]-3-methylprop-2-enoate; In tetrahydrofuran; at -78 - 0 ℃; for 3.5h;
DOI:10.1039/b203482d

Reference yield:

: 420803-52-7
((1R,2R)-1-Benzyl-2-hydroxy-2,3-dimethyl-but-3-enyl)-carbamic acid tert-butyl ester

: 420803-67-4
tert-butyl (2R,5R,3E)-5-[N-(tert-butyloxycarbonyl)amino]-2-isopropyl-3,4-dimethyl-6-phenylhex-3-enoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: NaH / tetrahydrofuran / Heating

1.2: 98 percent / tetrahydrofuran / 0 - 20 °C

2.1: O₃ / ethyl acetate / -78 °C

2.2: Me₂S / ethyl acetate / 0 °C

3.1: 3.08 g / CHCl₃ / 24 h / Heating

4.1: CuCN; LiCl / tetrahydrofuran / 0.17 h / 0 °C

4.2: BF₃*Et₂O / tetrahydrofuran / 0.08 h / -78 °C

4.3: 75 percent / tetrahydrofuran / 3.5 h / -78 - 0 °C

With sodium hydride; ozone; lithium chloride; In tetrahydrofuran; chloroform; ethyl acetate; 3.1: Wittig reaction;
DOI:10.1039/b203482d

Reference yield:

: 115186-33-9
(R)-tert-butyl (1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate

: 420803-67-4
tert-butyl (2R,5R,3E)-5-[N-(tert-butyloxycarbonyl)amino]-2-isopropyl-3,4-dimethyl-6-phenylhex-3-enoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: tetrahydrofuran

2.1: CeCl₃ / tetrahydrofuran

3.1: NaH / tetrahydrofuran / Heating

3.2: 98 percent / tetrahydrofuran / 0 - 20 °C

4.1: O₃ / ethyl acetate / -78 °C

4.2: Me₂S / ethyl acetate / 0 °C

5.1: 3.08 g / CHCl₃ / 24 h / Heating

6.1: CuCN; LiCl / tetrahydrofuran / 0.17 h / 0 °C

6.2: BF₃*Et₂O / tetrahydrofuran / 0.08 h / -78 °C

6.3: 75 percent / tetrahydrofuran / 3.5 h / -78 - 0 °C

With cerium(III) chloride; sodium hydride; ozone; lithium chloride; In tetrahydrofuran; chloroform; ethyl acetate; 2.1: Grignard addition / 5.1: Wittig reaction;
DOI:10.1039/b203482d