ethyl 7-methyl-2,4-dioxo-3-phenyl-1-[4-(4-pyrimidin-2-ylpiperazin-1-yl)butyl]-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidine-5-carboxylate

Base Information

Chemical Name:ethyl 7-methyl-2,4-dioxo-3-phenyl-1-[4-(4-pyrimidin-2-ylpiperazin-1-yl)butyl]-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidine-5-carboxylate
CAS No.:160031-37-8
Molecular Formula:C₂₉H₃₃N₇O₄
Molecular Weight:543.626
Hs Code.:
Mol file:160031-37-8.mol

ethyl 7-methyl-2,4-dioxo-3-phenyl-1-[4-(4-pyrimidin-2-ylpiperazin-1-yl)butyl]-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidine-5-carboxylate

Synonyms:NSC 683340

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of ethyl 7-methyl-2,4-dioxo-3-phenyl-1-[4-(4-pyrimidin-2-ylpiperazin-1-yl)butyl]-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidine-5-carboxylate

Chemical Property:

Vapor Pressure:5.77E-22mmHg at 25°C
Boiling Point:743.3°C at 760 mmHg
Flash Point:403.3°C
Density:1.278g/cm³

Purity/Quality:: 99% ，98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of ethyl 7-methyl-2,4-dioxo-3-phenyl-1-[4-(4-pyrimidin-2-ylpiperazin-1-yl)butyl]-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidine-5-carboxylate

There total 2 articles about ethyl 7-methyl-2,4-dioxo-3-phenyl-1-[4-(4-pyrimidin-2-ylpiperazin-1-yl)butyl]-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidine-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 20980-22-7
N-(2-pyridinyl)piperazine

: 160031-33-4
ethyl 1-(4-bromobutyl)-3-phenyl-7-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrido<2,3-d>pyrimidine-5-carboxylate

: 160031-37-8
7-Methyl-2,4-dioxo-3-phenyl-1-[4-(4-pyrimidin-2-yl-piperazin-1-yl)-butyl]-1,2,3,4-tetrahydro-pyrido[2,3-d]pyrimidine-5-carboxylic acid ethyl ester

Guidance literature:: With potassium carbonate; In acetonitrile; for 10h; Heating;

Reference yield:

: 131448-03-8
ethyl 7-methyl-3-phenyl-2,4-dioxo-1,2,3,4-tetrahydropyrido<2,3-d>pyrimidine-5-carboxylate

: 160031-37-8
7-Methyl-2,4-dioxo-3-phenyl-1-[4-(4-pyrimidin-2-yl-piperazin-1-yl)-butyl]-1,2,3,4-tetrahydro-pyrido[2,3-d]pyrimidine-5-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) K/EtOH / 2.) DMF, r.t., 5 h

2: 65 percent / K₂CO₃ / acetonitrile / 10 h / Heating

With ethanol; potassium carbonate; In acetonitrile;