2-Propynoyl chloride, 3-(4-chlorophenyl)-

Base Information

• Chemical Name: 2-Propynoyl chloride, 3-(4-chlorophenyl)-
• CAS No.: 42122-34-9
• Molecular Formula: C9H4Cl2O
• Molecular Weight: 199.036
• Mol file: 42122-34-9.mol

Synonyms:

Chemical Property of 2-Propynoyl chloride, 3-(4-chlorophenyl)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Propynoyl chloride, 3-(4-chlorophenyl)-

There total 7 articles about 2-Propynoyl chloride, 3-(4-chlorophenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(4-chlorophenyl)propiolic acid (3240-10-6) → 3-(4-chlorophenyl)propioloyl chloride (42122-34-9)

Guidance literature:

With thionyl chloride; In dichloromethane; for 12h; Inert atmosphere; Reflux;

DOI:10.1002/chem.201900947

Reference yield: 77.0%

C9H4ClO2(1-)*K(1+) → 3-(4-chlorophenyl)propioloyl chloride (42122-34-9)

Guidance literature:

With thionyl chloride;

DOI:10.3762/bjoc.17.180

Reference yield:

ethyl 3-(4-chlorophenyl)propiolate (20026-96-4) → 3-(4-chlorophenyl)propioloyl chloride (42122-34-9)

Guidance literature:

Multi-step reaction with 2 steps

1: NaOH, benzyltriethylammonium chloride / H₂O; diethyl ether / 120 h

2: 1.) aq. NaOH, 2.) SOCl₂ / 2) ether, reflux, 6 h

With sodium hydroxide; thionyl chloride; N-benzyl-N,N,N-triethylammonium chloride; In diethyl ether; water;

DOI:10.1039/P19940002461

upstream raw materials:

(4-chlorophenyl)propiolic acid

ethyl 3-(4-chlorophenyl)propiolate

4-chlorobenzaldehyde

p-chlorocinnamic acid

Downstream raw materials:

1-(4-chlorophenyl)-7-chloro-2,3-naphthalenedicarboxylic anhydride

7-chloro-1-(2-chloro-phenyl)-naphthalene-2,3-dicarboxylic acid-anhydride

3-(4-chlorophenyl)-2-propynamide

N-cyclopropylmethyl-14β-[4'-chlorophenylpropioloylamino]-7,8-dihydronorcodeinone