3-Heptanol, 7-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-5-[2-[[(1,1-dimethylethyl)diphenyl silyl]oxy]ethyl]-1-[(4-methoxyphenyl)methoxy]-2-methyl-, (2R,3R,5R)-

Base Information

Chemical Name:3-Heptanol, 7-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-5-[2-[[(1,1-dimethylethyl)diphenyl silyl]oxy]ethyl]-1-[(4-methoxyphenyl)methoxy]-2-methyl-, (2R,3R,5R)-
CAS No.:423151-67-1
Molecular Formula:C40H62O5Si2
Molecular Weight:679.1
Hs Code.:
Mol file:423151-67-1.mol

3-Heptanol,
7-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-5-[2-[[(1,1-dimethylethyl)diphenyl
silyl]oxy]ethyl]-1-[(4-methoxyphenyl)methoxy]-2-methyl-, (2R,3R,5R)-

Synonyms:

Suppliers and Price of 3-Heptanol, 7-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-5-[2-[[(1,1-dimethylethyl)diphenyl silyl]oxy]ethyl]-1-[(4-methoxyphenyl)methoxy]-2-methyl-, (2R,3R,5R)-

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-Heptanol, 7-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-5-[2-[[(1,1-dimethylethyl)diphenyl silyl]oxy]ethyl]-1-[(4-methoxyphenyl)methoxy]-2-methyl-, (2R,3R,5R)-

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

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Useful:

Technology Process of 3-Heptanol, 7-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-5-[2-[[(1,1-dimethylethyl)diphenyl silyl]oxy]ethyl]-1-[(4-methoxyphenyl)methoxy]-2-methyl-, (2R,3R,5R)-

There total 12 articles about 3-Heptanol, 7-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-5-[2-[[(1,1-dimethylethyl)diphenyl silyl]oxy]ethyl]-1-[(4-methoxyphenyl)methoxy]-2-methyl-, (2R,3R,5R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 58479-61-1
tert-butylchlorodiphenylsilane

: 423118-49-4
(3S,5R,6R)-3-[2-(tert-butyldimethylsilanyloxy)-ethyl]-7-(4-methoxybenzyloxy)-6-methylheptane-1,5-diol

: 423151-67-1
(3S,3R,5R)-5-[2-(tert-butyldimethylsilanyloxy)-ethyl]-7-(tert-butyldiphenylsilanyloxy)-1-(4-methoxybenzyloxy)-2-methylheptan-3-ol

Guidance literature:: With 1H-imidazole; In dichloromethane; at 20 ℃; for 2h;
DOI:10.1016/S0040-4039(01)02154-2 DOI:10.1039/b507570j

Reference yield:

: 89238-99-3
O-(4-methoxybenzyl)-trichloroacetimidate

: 423151-67-1
(3S,3R,5R)-5-[2-(tert-butyldimethylsilanyloxy)-ethyl]-7-(tert-butyldiphenylsilanyloxy)-1-(4-methoxybenzyloxy)-2-methylheptan-3-ol

Guidance literature:: Multi-step reaction with 5 steps

1.1: 62 percent / camphorsulfonic acid / CH₂Cl₂ / 72 h / 0 °C

2.1: 99 percent / tetrabutylammonium fluoride / tetrahydrofuran / 2 h / 20 °C

3.1: 82 percent / imidazole / CH₂Cl₂ / 2 h / 20 °C

4.1: 9-BBN / tetrahydrofuran / 12.5 h / 0 - 20 °C

4.2: 95 percent / aq. NaOH; H₂O₂ / tetrahydrofuran / 4 h / 0 °C

5.1: 96 percent / imidazole / CH₂Cl₂ / 2 h / 20 °C

With 1H-imidazole; 9-borabicyclo[3.3.1]nonane dimer; camphor-10-sulfonic acid; tetrabutyl ammonium fluoride; In tetrahydrofuran; dichloromethane;
DOI:10.1039/b507570j

Reference yield:

: 423117-81-1
(α)-3-[2-(tert-butyldiphenylsilanyloxy)-ethyl]-pent-4-enal

: 423151-67-1
(3S,3R,5R)-5-[2-(tert-butyldimethylsilanyloxy)-ethyl]-7-(tert-butyldiphenylsilanyloxy)-1-(4-methoxybenzyloxy)-2-methylheptan-3-ol

Guidance literature:: Multi-step reaction with 7 steps

1.1: Bu₂BOTf; i-Pr₂NEt / CH₂Cl₂ / 0.5 h / -78 °C

1.2: 39 percent / CH₂Cl₂ / 2 h / -78 - 20 °C

2.1: 96 percent / LiBH₄ / methanol; diethyl ether / 2.5 h / 0 - 20 °C

3.1: 62 percent / camphorsulfonic acid / CH₂Cl₂ / 72 h / 0 °C

4.1: 99 percent / tetrabutylammonium fluoride / tetrahydrofuran / 2 h / 20 °C

5.1: 82 percent / imidazole / CH₂Cl₂ / 2 h / 20 °C

6.1: 9-BBN / tetrahydrofuran / 12.5 h / 0 - 20 °C

6.2: 95 percent / aq. NaOH; H₂O₂ / tetrahydrofuran / 4 h / 0 °C

7.1: 96 percent / imidazole / CH₂Cl₂ / 2 h / 20 °C

With 1H-imidazole; lithium borohydride; 9-borabicyclo[3.3.1]nonane dimer; di-n-butylboryl trifluoromethanesulfonate; camphor-10-sulfonic acid; tetrabutyl ammonium fluoride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; 1.2: Evans aldol reaction;
DOI:10.1039/b507570j