Technology Process of Boronic acid, [4-fluoro-3-(3-fluoro-2-pyridinyl)phenyl]-
There total 4 articles about Boronic acid, [4-fluoro-3-(3-fluoro-2-pyridinyl)phenyl]- which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
2-(5-bromo-2-fluorophenyl)-3-fluoropyridine;
With
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; 2-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)-5,5-dimethyl-1,3,2-dioxaborinane;
In
1,4-dioxane; dichloromethane;
at 80 ℃;
for 18h;
With
hydrogenchloride;
at 45 ℃;
for 0.5h;
DOI:10.1021/jm051144x
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: 69 percent / dibromodimethylhydantoin; sulfuric acid / acetonitrile / 2 h / 55 °C
2.1: bis(neopentylglycolato)diboron; potassium acetate; dichloro[1,1'-bis(diphenylphosphino)ferrocene]palladium(II) / dioxane; CH2Cl2 / 18 h / 80 °C
2.2: 94 percent / aq. HCl / 0.5 h / 45 °C
With
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; sulfuric acid; potassium acetate; 2-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)-5,5-dimethyl-1,3,2-dioxaborinane;
In
1,4-dioxane; dichloromethane; acetonitrile;
DOI:10.1021/jm051144x
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 86 percent / potassium fluoride; tris(dibenzylideneacetone)dipalladium (0); tri-tert-butylphosphine / tetrahydrofuran; H2O; hexane / 24 h / 55 °C
2.1: 69 percent / dibromodimethylhydantoin; sulfuric acid / acetonitrile / 2 h / 55 °C
3.1: bis(neopentylglycolato)diboron; potassium acetate; dichloro[1,1'-bis(diphenylphosphino)ferrocene]palladium(II) / dioxane; CH2Cl2 / 18 h / 80 °C
3.2: 94 percent / aq. HCl / 0.5 h / 45 °C
With
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium fluoride; tris(dibenzylideneacetone)dipalladium (0); 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; tri-tert-butyl phosphine; sulfuric acid; potassium acetate; 2-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)-5,5-dimethyl-1,3,2-dioxaborinane;
In
tetrahydrofuran; 1,4-dioxane; hexane; dichloromethane; water; acetonitrile;
1.1: Suzuki coupling;
DOI:10.1021/jm051144x
