4-Thiazolecarboxylic acid, 2-[3-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-1-azetidinyl]-, (4-nitrophenyl)methyl ester

Base Information

Chemical Name:4-Thiazolecarboxylic acid, 2-[3-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-1-azetidinyl]-, (4-nitrophenyl)methyl ester
CAS No.:429666-57-9
Molecular Formula:C30H31N3O5SSi
Molecular Weight:573.745
Hs Code.:
Mol file:429666-57-9.mol

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Suppliers and Price of 4-Thiazolecarboxylic acid, 2-[3-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-1-azetidinyl]-, (4-nitrophenyl)methyl ester

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Chemical Property of 4-Thiazolecarboxylic acid, 2-[3-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-1-azetidinyl]-, (4-nitrophenyl)methyl ester

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Technology Process of 4-Thiazolecarboxylic acid, 2-[3-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-1-azetidinyl]-, (4-nitrophenyl)methyl ester

There total 1 articles about 4-Thiazolecarboxylic acid, 2-[3-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-1-azetidinyl]-, (4-nitrophenyl)methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

: 619-73-8
4-nitrobenzyl chloride

: 429666-56-8
3-t-butyldiphenylsilyloxy-1-(4-carboxyl-1,3-thiazol-2-yl)azetidine

: 429666-57-9
3-t-butyldiphenylsilyloxy-1-(4-p-nitrobenzyloxycarbonyl-1,3-thiazol-2-yl)azetidine

Guidance literature:: 3-t-butyldiphenylsilyloxy-1-(4-carboxyl-1,3-thiazol-2-yl)azetidine; With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 0 ℃; for 2h;

4-nitrobenzyl chloride; With triethylamine; In dichloromethane; at 0 ℃; for 1h;

With sodium hydrogencarbonate; In dichloromethane; water; ethyl acetate;

Reference yield: 81.0%

: 429666-57-9
3-t-butyldiphenylsilyloxy-1-(4-p-nitrobenzyloxycarbonyl-1,3-thiazol-2-yl)azetidine

: 429666-59-1
1-(4-p-nitrobenzyloxycarbonyl-1,3-thiazol-2-yl)-3-hydroxyazetidine

Guidance literature:: 3-t-butyldiphenylsilyloxy-1-(4-p-nitrobenzyloxycarbonyl-1,3-thiazol-2-yl)azetidine; With tetrabutyl ammonium fluoride; acetic acid; In tetrahydrofuran; at 0 ℃; for 2h;

With sodium hydrogencarbonate; In tetrahydrofuran; water; ethyl acetate;