1-Azetidinecarboxylic acid, 3-[[[2-[3-(acetylthio)-1-azetidinyl]-4-thiazolyl]carbonyl]amino]-, (4-nitrophenyl)methyl ester

Base Information

Chemical Name:1-Azetidinecarboxylic acid, 3-[[[2-[3-(acetylthio)-1-azetidinyl]-4-thiazolyl]carbonyl]amino]-, (4-nitrophenyl)methyl ester
CAS No.:429671-60-3
Molecular Formula:C20H21N5O6S2
Molecular Weight:491.549
Hs Code.:
Mol file:429671-60-3.mol

Synonyms:

Suppliers and Price of 1-Azetidinecarboxylic acid, 3-[[[2-[3-(acetylthio)-1-azetidinyl]-4-thiazolyl]carbonyl]amino]-, (4-nitrophenyl)methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1-Azetidinecarboxylic acid, 3-[[[2-[3-(acetylthio)-1-azetidinyl]-4-thiazolyl]carbonyl]amino]-, (4-nitrophenyl)methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-Azetidinecarboxylic acid, 3-[[[2-[3-(acetylthio)-1-azetidinyl]-4-thiazolyl]carbonyl]amino]-, (4-nitrophenyl)methyl ester

There total 2 articles about 1-Azetidinecarboxylic acid, 3-[[[2-[3-(acetylthio)-1-azetidinyl]-4-thiazolyl]carbonyl]amino]-, (4-nitrophenyl)methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 429671-73-8
3-methanesulfonyloxy-1-{4-[(1-p-nitrobenzyloxycarbonyl)-azetidin-3-ylcarbamoyl]-1,3-thiazol-2-yl}azetidine

: 10387-40-3
potassium thioacetate

: 429671-60-3
3-acetylthio-1-{4-[1-(p-nitrobenzyloxycarbonyl)-azetidin-3-ylcarbamoyl]-1,3-thiazol-2-yl}azetidine

Guidance literature:: 3-methanesulfonyloxy-1-{4-[(1-p-nitrobenzyloxycarbonyl)-azetidin-3-ylcarbamoyl]-1,3-thiazol-2-yl}azetidine; potassium thioacetate; In DMF (N,N-dimethyl-formamide); at 20 - 80 ℃;

With sodium hydrogencarbonate; In DMF (N,N-dimethyl-formamide); water; ethyl acetate;

Reference yield:

: 429671-71-6
3-hydroxy-1-{4-[(1-p-nitrobenzyloxycarbonyl)-azetidin-3-ylcarbamoyl]-1,3-thiazol-2-yl}azetidine

: 429671-60-3
3-acetylthio-1-{4-[1-(p-nitrobenzyloxycarbonyl)-azetidin-3-ylcarbamoyl]-1,3-thiazol-2-yl}azetidine

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane

2: N-methyl-acetamide

With triethylamine; In N-methyl-acetamide; dichloromethane;

Reference yield: 77.0%

: 429671-60-3
3-acetylthio-1-{4-[1-(p-nitrobenzyloxycarbonyl)-azetidin-3-ylcarbamoyl]-1,3-thiazol-2-yl}azetidine

: 93711-81-0,90776-59-3,189188-38-3
(4-nitrophenyl)methyl (4R,5R,6S)-3-[(diphenoxyphosphinyl)oxy]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate

: p-nitrobenzyl (1R,5S,6S)-2-(1-{4-[1-(p-nitrobenzyloxycarbonyl)-azetidin-3-ylcarbamoyl]-1,3-thiazol-2-yl}azetidin-3-yl)thio-6-[(R)-1-hydroxyethyl]-1-methylcarbapen-2-em-3-carboxylate

Guidance literature:: 3-acetylthio-1-{4-[1-(p-nitrobenzyloxycarbonyl)-azetidin-3-ylcarbamoyl]-1,3-thiazol-2-yl}azetidine; With hydrazinium monoacetate; In DMF (N,N-dimethyl-formamide); at 20 ℃; for 1h;

(4-nitrophenyl)methyl (4R,5R,6S)-3-[(diphenoxyphosphinyl)oxy]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate; With N-ethyl-N,N-diisopropylamine; In DMF (N,N-dimethyl-formamide); acetonitrile; at 0 - 20 ℃;

With sodium hydrogencarbonate; In DMF (N,N-dimethyl-formamide); water; ethyl acetate; acetonitrile;