2-Diethoxyphosphoryl-2-phenylacetonitrile

Base Information

Chemical Name:2-Diethoxyphosphoryl-2-phenylacetonitrile
CAS No.:43055-48-7
Molecular Formula:C12H16NO3P
Molecular Weight:253.238
Hs Code.:
DSSTox Substance ID:DTXSID40542631
Nikkaji Number:J337.242A
Mol file:43055-48-7.mol

Synonyms:diethyl cyano(phenyl)methylphosphonate;43055-48-7;2-diethoxyphosphoryl-2-phenylacetonitrile;diethyl 1-cyano-1-phenylmethylphosphonate;diethyl a-cyanobenzylphosphonate;SCHEMBL7110345;DTXSID40542631;OOAAVAAUXUISIN-UHFFFAOYSA-N;Diethyl [cyano(phenyl)methyl]phosphonate

Suppliers and Price of 2-Diethoxyphosphoryl-2-phenylacetonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of 2-Diethoxyphosphoryl-2-phenylacetonitrile

Chemical Property:

XLogP3:1.7
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:6
Exact Mass:253.08678037
Heavy Atom Count:17
Complexity:307

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOP(=O)(C(C#N)C1=CC=CC=C1)OCC

Technology Process of 2-Diethoxyphosphoryl-2-phenylacetonitrile

There total 9 articles about 2-Diethoxyphosphoryl-2-phenylacetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 140-29-4
phenylacetonitrile

: 814-49-3
diethyl chlorophosphate

: 43055-48-7
Diethyl <α-cyano-α-phenylmethyl>phosphonate

Guidance literature:: phenylacetonitrile; With lithium hexamethyldisilazane; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h;

diethyl chlorophosphate; In tetrahydrofuran; at -78 - 0 ℃; for 0.25h;

With hydrogenchloride; In tetrahydrofuran; hexane; Further stages.;
DOI:10.1039/b003371p

Reference yield: 85.0%

: 591-50-4
iodobenzene

: 2537-48-6
diethyl 1-cyanomethylphosphonate

: 43055-48-7
Diethyl <α-cyano-α-phenylmethyl>phosphonate

Guidance literature:: With sodium hydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; for 3h; Heating;
DOI:10.1248/cpb.38.1513

Reference yield: 80.0%

: 108-86-1,52753-63-6
bromobenzene

: 2537-48-6
diethyl 1-cyanomethylphosphonate

: 43055-48-7
Diethyl <α-cyano-α-phenylmethyl>phosphonate

Guidance literature:: With sodium hydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; for 5h; Heating;
DOI:10.1248/cpb.38.1513