1-(3-Hydroxy-5-Methylphenyl)ethanone

Base Information

• Chemical Name: 1-(3-Hydroxy-5-Methylphenyl)ethanone
• CAS No.: 43113-93-5
• Molecular Formula: C₉H₁₀O₂
• Molecular Weight: 150.177
• Mol file: 43113-93-5.mol

Synonyms:1-(3-hydroxy-5-methyl-phenyl)-ethanone;3-Hydroxy-5-methylacetophenon;3-Hydroxy-5-methyl-acetophenon;1-(3-Hydroxy-5-methylphenyl)ethanone;1-(3-Hydroxy-5-methyl-phenyl)-aethanon;

Chemical Property of 1-(3-Hydroxy-5-Methylphenyl)ethanone

Chemical Property:

• Melting Point: 122–123°C
• PSA: 37.30000
• LogP: 1.90320
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

1-(3-Hydroxy-5-methylphenyl)ethanone 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(3-Hydroxy-5-Methylphenyl)ethanone

There total 10 articles about 1-(3-Hydroxy-5-Methylphenyl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

5-acetyl-3-methyl-2-cyclohexen-1-one (43113-92-4) → 3-acetyl-5-methylphenol (43113-93-5)

Guidance literature:

With acetonitrile; lithium bromide; copper(ll) bromide; for 1h; Heating;

DOI:10.1016/0040-4020(82)85023-0

Reference yield: 36.0%

1-[3-Methyl-5-(tetrahydro-pyran-2-yloxy)-phenyl]-ethanone (85288-59-1) → 3-acetyl-5-methylphenol (43113-93-5)

Guidance literature:

With toluene-4-sulfonic acid; In methanol; for 25h; Ambient temperature;

DOI:10.1016/0040-4020(82)85023-0

Reference yield:

3-bromo-5-methylphenol (74204-00-5) → 3-acetyl-5-methylphenol (43113-93-5)

Guidance literature:

Multi-step reaction with 4 steps

1: HCl, EtOAc / 24 h / Ambient temperature

2: 1)t-BuLi / 1)-65 deg C, THF, pentane, 2 h 2) -65 deg C, THF, 5 min

3: 93 percent / C₅H₅NHCrO₃Cl, NaOAc / CH₂Cl₂ / 4 h / Ambient temperature

4: 36 percent / p-MeC₆H₄SO₃H*H₂O / methanol / 25 h / Ambient temperature

With hydrogenchloride; Pyr*CrO₃*HCl; tert.-butyl lithium; sodium acetate; toluene-4-sulfonic acid; ethyl acetate; In methanol; dichloromethane;

DOI:10.1016/0040-4020(82)85023-0

upstream raw materials:

3-acetoxy-5-methyl-benzoyl chloride

5-acetyl-3-methyl-2-cyclohexen-1-one

1-[3-Methyl-5-(tetrahydro-pyran-2-yloxy)-phenyl]-ethanone

4-acetyl-4-ethoxycarbonyl-2,6-heptanedione

Downstream raw materials:

1-(3-hydroxy-5-methyl-2,4,6-trinitro-phenyl)-ethanone

1-(3-hydroxy-5-methyl-4-nitro-phenyl)-ethanone

1-(3-hydroxy-5-methyl-2-nitro-phenyl)-ethanone