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Technology Process of N-(6-chloro-9h-pyrido[3,4-b]indol-8-yl)-3-pyridinecarboxamide

N-(6-chloro-9h-pyrido[3,4-b]indol-8-yl)-3-pyridinecarboxamide

Base Information
  • Chemical Name:N-(6-chloro-9h-pyrido[3,4-b]indol-8-yl)-3-pyridinecarboxamide
  • CAS No.:431898-65-6
  • Molecular Formula:C17H11ClN4O
  • Molecular Weight:322.74800
  • Hs Code.:
  • UNII:12GL090NZZ
  • DSSTox Substance ID:DTXSID00433238
  • Nikkaji Number:J1.734.712H
  • Wikidata:Q27166575
  • ChEMBL ID:CHEMBL79004
  • Mol file:431898-65-6.mol
N-(6-chloro-9h-pyrido[3,4-b]indol-8-yl)-3-pyridinecarboxamide

Synonyms:PS-1145;PS1145

Suppliers and Price of N-(6-chloro-9h-pyrido[3,4-b]indol-8-yl)-3-pyridinecarboxamide
Supply Marketing:
Business phase:
The product has achieved commercial mass production*data from LookChem market partment
Manufacturers and distributors:
  • Manufacture/Brand
  • Chemicals and raw materials
  • Packaging
  • price
  • Usbiological
  • PS 1145 dihydrochloride
  • 10mg
  • $ 452.00
  • TRC
  • N-(6-Chloro-9H-pyrido[3,4-b]indol-8-yl)-3-pyridinecarboxamide
  • 10mg
  • $ 305.00
  • Tocris
  • PS-1145 dihydrochloride ≥98%(HPLC)
  • 10
  • $ 199.00
  • Sigma-Aldrich
  • PS-1145 dihydrochloride ≥98% (HPLC), solid
  • 5mg
  • $ 179.00
  • Sigma-Aldrich
  • PS-1145 dihydrochloride ≥98% (HPLC), solid
  • 25mg
  • $ 716.00
  • DC Chemicals
  • PS-1145 >98%
  • 1 g
  • $ 1800.00
  • Crysdot
  • PS-1145 98+%
  • 100mg
  • $ 1015.00
  • Crysdot
  • PS-1145 98+%
  • 25mg
  • $ 297.00
  • Crysdot
  • PS-1145 98+%
  • 50mg
  • $ 574.00
  • ChemScene
  • PS-1145 99.88%
  • 25mg
  • $ 396.00
Total 26 raw suppliers
Chemical Property of N-(6-chloro-9h-pyrido[3,4-b]indol-8-yl)-3-pyridinecarboxamide
Chemical Property:
  • Boiling Point:511.0±50.0 °C(Predicted) 
  • PKA:11.75±0.43(Predicted) 
  • PSA：74.16000 
  • Density:1.513±0.06 g/cm3(Predicted) 
  • LogP:4.40080 
  • Storage Temp.:2-8°C 
  • Solubility.:DMSO: >3mg/mL at ~60°C, clear (with warming for 2 minutes) 
  • XLogP3:2.7
  • Hydrogen Bond Donor Count:2
  • Hydrogen Bond Acceptor Count:3
  • Rotatable Bond Count:2
  • Exact Mass:322.0621387
  • Heavy Atom Count:23
  • Complexity:448
Purity/Quality:

99%, *data from raw suppliers

PS 1145 dihydrochloride *data from reagent suppliers

Safty Information:
  • Pictogram(s): Xn 
  • Hazard Codes:Xn 
  • Statements: 22 
MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:
  • Canonical SMILES:C1=CC(=CN=C1)C(=O)NC2=CC(=CC3=C2NC4=C3C=CN=C4)Cl
  • Uses N-(6-Chloro-9H-pyrido[3,4-b]indol-8-yl)-3-pyridinecarboxamide is an inhibitor of IKKβ, an enzyme involved with the cytokine-activated intracellular signaling pathway that regulates the immune response. N-(6-Chloro-9H-pyrido[3,4-b]indol-8-yl)-3-pyridinecarboxamide also inhibits osteoclast differentiation. PS-1145 dihydrochloride has been used as an IκB kinase (IKK) inhibitor: in the culture medium to treat human epidermal keratinocytes (HEKs) and squamous carcinoma cells (SCCs) to study the role of IKK in?Corynebacterium tuberculostearicum?(C. t.)-elicited transcription of inflammatory mediators to investigate the involvement of transcription factor p65 (RelA)/nuclear factor kappa-B (NF-κB) in the cluster of differentiation 28 (CD28)-mediated interleukin-17A (IL-17A) gene expression to examine the involvement of NF-κB signaling in the cytotoxic effect of niclosamide on colorectal cancer (CRC) cells
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