5-methyl-3-phenylisoxazole-4-carboxamide

Base Information

• Chemical Name: 5-methyl-3-phenylisoxazole-4-carboxamide
• CAS No.: 4340-44-7
• Molecular Formula: C11H10N2O2
• Molecular Weight: 202.20900
• Hs Code.: 2934999090
• Mol file: 4340-44-7.mol

Synonyms:5-methyl-3-phenyl-isoxazole-4-carbaldehyde;3-phenyl-5-methyl-4-isoxazolecarbaldehyde;5-methyl-3-phenyl-4-isoxazole carboxaldehyde;5-methyl-3-phenyl-isoxazole-4-carboxylic acid amide;5-Methyl-3-phenyl-isoxazol-4-carbaldehyd;5-methyl-3-phenylisoxazole-4-carboxaldehyde;5-Methyl-3-phenylisoxazol-4-carboxamid;5-Methyl-3-phenyl-isoxazol-4-carbonsaeure-amid;5-METHYL-3-PHENYL-4-ISOXAZOLECARBALDEHYDE;

Chemical Property of 5-methyl-3-phenylisoxazole-4-carboxamide

Chemical Property:

• PSA: 70.11000
• LogP: 2.63310

Purity/Quality:

99%, ^*data from raw suppliers

5-Methyl-3-phenyl-isoxazole-4-carboxylicacidamide 95%+ ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-methyl-3-phenylisoxazole-4-carboxamide

There total 5 articles about 5-methyl-3-phenylisoxazole-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

oxacillin (66-79-5,86555-25-1) → 5-methyl-3-phenylisoxazole-4-carboxamide (4340-44-7)

Guidance literature:

With sodium hydroxide; copper(II) sulfate; In water; for 0.0833333h; Heating;

Reference yield:

5-methyl-3-phenylisoxazole-4-carbonyl chloride (16883-16-2) → 5-methyl-3-phenylisoxazole-4-carboxamide (4340-44-7)

Guidance literature:

Reference yield:

5-methyl-3-phenylisoxazol-4-carboxylic acid (1136-45-4) → 5-methyl-3-phenylisoxazole-4-carboxamide (4340-44-7)

Guidance literature:

Multi-step reaction with 2 steps

1: SOCl₂ / 1,2-dichloro-ethane / 2 h / 80 °C

2: NH₃ / ethanol / 14 h / 0 - 20 °C

With thionyl chloride; ammonia; In ethanol; 1,2-dichloro-ethane;

DOI:10.1016/j.bmcl.2006.09.062

upstream raw materials:

5-methyl-3-phenylisoxazole-4-carbonyl chloride

oxacillin

5-methyl-3-phenylisoxazol-4-carboxylic acid

Bristopen

Downstream raw materials:

5-methyl-3-phenylisoxazole-4-carbonitrile

[4-(5-methyl-3-phenyl-isoxazol-4-ylsulfamoyl)-phenyl]-carbamic acid methyl ester

4-amino-N-(5-methyl-3-phenyl-isoxazol-4-yl)-benzenesulfonamide

3-phenyl-5-styrylisoxazole-4-carbonitrile