Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-5-methyl-2'-O-[2-[(trifluoroacet yl)amino]ethyl]-

Base Information

Chemical Name:Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-5-methyl-2'-O-[2-[(trifluoroacet yl)amino]ethyl]-
CAS No.:439081-07-9
Molecular Formula:C35H36F3N3O9
Molecular Weight:699.681
Hs Code.:

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-5-methyl-2'-O-[2-[(trifluoroacet yl)amino]ethyl]-

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-5-methyl-2'-O-[2-[(trifluoroacet yl)amino]ethyl]-

There total 12 articles about Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-5-methyl-2'-O-[2-[(trifluoroacet yl)amino]ethyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 911110-78-6
[2'-O-(2-trifluoroacetamido)ethyl-β-D-ribofuranosyl]thymine

: 439081-07-9
[5'-O-(4,4'-dimethoxytrityl)-2'-O-(2-trifluoroacetamido)ethyl-β-D-ribofuranosyl]thymine

Guidance literature:: With pyridine; at 20 ℃; for 3.5h;
DOI:10.1002/ejoc.200600182

Reference yield:

: 3-Benzyloxymethyl-1-((2R,3R,3aS,9aR)-3-hydroxy-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-5-methyl-1H-pyrimidine-2,4-dione

: 439081-07-9
[5'-O-(4,4'-dimethoxytrityl)-2'-O-(2-trifluoroacetamido)ethyl-β-D-ribofuranosyl]thymine

Guidance literature:: Multi-step reaction with 9 steps

1: 98 percent / NaH / dimethylformamide / 1.5 h / -5 °C

2: 84 percent / LiBH₄ / methanol; tetrahydrofuran / 1.5 h / 5 °C

3: 89 percent / NEt₃, DMAP / CH₂Cl₂ / 8 h / 22 °C

4: 88 percent / H₂, HCl / Pd/C / tetrahydrofuran; methanol / 7 h / 22 °C

5: 92 percent / NaN₃ / dimethylformamide / 3 h / 65 °C

6: 70 percent / SnCl₂ / methanol / 24 h / 22 °C

7: 57 percent / pyridine / 2 h / 22 °C

8: 100 percent / TBAF / tetrahydrofuran / 0.25 h / 22 °C

9: 85 percent / pyridine / 16 h / 22 °C

With pyridine; hydrogenchloride; dmap; lithium borohydride; sodium azide; tetrabutyl ammonium fluoride; hydrogen; sodium hydride; triethylamine; tin(ll) chloride; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/(SICI)1521-3773(19980518)37:9<1288::AID-ANIE1288>3.0.CO;2-U

Reference yield:

: 200423-86-5
2'-O-(2-hydroxyethyl)-3',5'-O-tetraisopropyl-di-siloxyl-N³-benzyloxymethyl-5-methyl uridine

: 439081-07-9
[5'-O-(4,4'-dimethoxytrityl)-2'-O-(2-trifluoroacetamido)ethyl-β-D-ribofuranosyl]thymine

Guidance literature:: Multi-step reaction with 7 steps

1: 89 percent / NEt₃, DMAP / CH₂Cl₂ / 8 h / 22 °C

2: 88 percent / H₂, HCl / Pd/C / tetrahydrofuran; methanol / 7 h / 22 °C

3: 92 percent / NaN₃ / dimethylformamide / 3 h / 65 °C

4: 70 percent / SnCl₂ / methanol / 24 h / 22 °C

5: 57 percent / pyridine / 2 h / 22 °C

6: 100 percent / TBAF / tetrahydrofuran / 0.25 h / 22 °C

7: 85 percent / pyridine / 16 h / 22 °C

With pyridine; hydrogenchloride; dmap; sodium azide; tetrabutyl ammonium fluoride; hydrogen; triethylamine; tin(ll) chloride; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/(SICI)1521-3773(19980518)37:9<1288::AID-ANIE1288>3.0.CO;2-U