[2-(AMINOMETHYL)-5-CHLOROPHENYL]METHANOL

Base Information

• Chemical Name: [2-(AMINOMETHYL)-5-CHLOROPHENYL]METHANOL
• CAS No.: 439117-39-2
• Molecular Formula: C8H10ClNO
• Molecular Weight: 171.626
• Mol file: 439117-39-2.mol

Synonyms:5-Bromo-thien-2-yl-methylamine;2-aminomethyl-5-bromothiophene;2-aminomethyl-5-chlorobenzyl alcohol;2-Hydroxymethyl-4-chloro-benzylamin;2-bromo-5-aminomethyl-thiophene;

Chemical Property of [2-(AMINOMETHYL)-5-CHLOROPHENYL]METHANOL

Chemical Property:

• PSA: 46.25000
• LogP: 1.99130

Purity/Quality:

97% ^*data from raw suppliers

[2-(AMINOMETHYL)-5-CHLOROPHENYL]METHANOL 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of [2-(AMINOMETHYL)-5-CHLOROPHENYL]METHANOL

There total 6 articles about [2-(AMINOMETHYL)-5-CHLOROPHENYL]METHANOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

methyl 5-chloro-2-cyanobenzoate (439117-38-1) → [2-(aminomethyl)-5-chlorophenyl]methanol (439117-39-2)

Guidance literature:

With zinc(II) tetrahydroborate; In tetrahydrofuran; toluene; at 60 ℃; for 12h;

DOI:10.1021/jo035794p

Reference yield:

methyl 5-chloro-2-[((trifluoromethyl)sulfonyl)oxy]benzoate (494210-98-9) → [2-(aminomethyl)-5-chlorophenyl]methanol (439117-39-2)

Guidance literature:

Multi-step reaction with 2 steps

1: Pd catalyst / 50 °C

2: BH₃*DMS

With dimethylsulfide borane complex; Pd catalyst;

DOI:10.1021/jo035794p

Reference yield:

2-bromo-5-chlorobenzoic acid (21739-93-5) → [2-(aminomethyl)-5-chlorophenyl]methanol (439117-39-2)

Guidance literature:

Multi-step reaction with 2 steps

1: HCl / 18 h / 20 °C

2: LiAlH₄ / tetrahydrofuran / 0.5 h / 0 °C

With hydrogenchloride; lithium aluminium tetrahydride; In tetrahydrofuran;

DOI:10.1016/S0960-894X(03)00732-7

upstream raw materials:

methyl 5-chloro-2-cyanobenzoate

methyl 5-chloro-2-[((trifluoromethyl)sulfonyl)oxy]benzoate

2-bromo-5-chlorobenzoic acid

2-bromo-3-chlorobenzoic acid

Downstream raw materials:

tert-butyl 4-chloro-2-(hydroxymethyl)benzylcarbamate

(4-chloro-2-chloromethyl-benzyl)-carbamic acid tert-butyl ester

N-fluorenylmethoxycarbonyl-L-prolyl-2-(tert-butyloxycarbonylaminomethyl)-5-chlorobenzylamide

[4-Chloro-2-({[(S)-1-((R)-2-hydroxy-3,3-dimethyl-butyryl)-pyrrolidine-2-carbonyl]-amino}-methyl)-benzyl]-carbamic acid tert-butyl ester