Phosphinic amide, N-[(1S)-2-nitro-1-phenylethyl]-P,P-diphenyl-

Base Information

Chemical Name:Phosphinic amide, N-[(1S)-2-nitro-1-phenylethyl]-P,P-diphenyl-
CAS No.:441012-04-0
Molecular Formula:C20H19N2O3P
Molecular Weight:366.356
Hs Code.:
DSSTox Substance ID:DTXSID30459648
Nikkaji Number:J1.693.640E
Wikidata:Q82283469

Synonyms:441012-04-0;Phosphinic amide, N-[(1S)-2-nitro-1-phenylethyl]-P,P-diphenyl-;DTXSID30459648;N-[(S)-alpha-(Nitromethyl)benzyl]diphenylphosphinamide

Suppliers and Price of Phosphinic amide, N-[(1S)-2-nitro-1-phenylethyl]-P,P-diphenyl-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of Phosphinic amide, N-[(1S)-2-nitro-1-phenylethyl]-P,P-diphenyl-

Chemical Property:

XLogP3:3.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:6
Exact Mass:366.11332947
Heavy Atom Count:26
Complexity:468

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C(C=C1)C(C[N+](=O)[O-])NP(=O)(C2=CC=CC=C2)C3=CC=CC=C3
Isomeric SMILES:C1=CC=C(C=C1)[C@@H](C[N+](=O)[O-])NP(=O)(C2=CC=CC=C2)C3=CC=CC=C3

Technology Process of Phosphinic amide, N-[(1S)-2-nitro-1-phenylethyl]-P,P-diphenyl-

There total 4 articles about Phosphinic amide, N-[(1S)-2-nitro-1-phenylethyl]-P,P-diphenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 75-52-5
nitromethane

: 98837-46-8
N-benzylidenediphenylphosphinamide

: 441012-04-0
(S)-(-)-N-(2-nitro-1-phenylethyl)diphenylphosphine amide

: (R)-N-(2-nitro-1-phenylethyl) diphenylphosphinamide

Guidance literature:: With YbKH₂[(R)-binaphtoxide]3; In tetrahydrofuran; toluene; at -40 ℃;
DOI:10.1246/cl.2002.276

Reference yield:

: 932-90-1
Benzaldoxime

: 441012-04-0
(S)-(-)-N-(2-nitro-1-phenylethyl)diphenylphosphine amide

: (R)-N-(2-nitro-1-phenylethyl) diphenylphosphinamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / dichloromethane; hexane / 0.17 h / -40 °C / Inert atmosphere

1.2: -40 - 20 °C / Inert atmosphere

2.1: iron(II) triflate; (S,S)-2,6-bis(4-phenyl-2-oxazolinyl)pyridine / tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere

2.2: 2 h / 20 °C / Inert atmosphere

With iron(II) triflate; triethylamine; (S,S)-2,6-bis(4-phenyl-2-oxazolinyl)pyridine; In tetrahydrofuran; hexane; dichloromethane; 2.1: |Mannich Aminomethylation / 2.2: |Mannich Aminomethylation;
DOI:10.1021/acs.joc.7b01786

Reference yield:

: 1079-66-9,74391-44-9
chloro-diphenylphosphine

: 441012-04-0
(S)-(-)-N-(2-nitro-1-phenylethyl)diphenylphosphine amide

: (R)-N-(2-nitro-1-phenylethyl) diphenylphosphinamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / dichloromethane; hexane / 0.17 h / -40 °C / Inert atmosphere

1.2: -40 - 20 °C / Inert atmosphere

2.1: iron(II) triflate; (S,S)-2,6-bis(4-phenyl-2-oxazolinyl)pyridine / tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere

2.2: 2 h / 20 °C / Inert atmosphere

With iron(II) triflate; triethylamine; (S,S)-2,6-bis(4-phenyl-2-oxazolinyl)pyridine; In tetrahydrofuran; hexane; dichloromethane; 2.1: |Mannich Aminomethylation / 2.2: |Mannich Aminomethylation;
DOI:10.1021/acs.joc.7b01786